Abstract: Objective To investigate the distribution of breast invasive ductal carcinoma with different molecular subtypes,and to study the relationship between molecular subtypes and clinical pathological features in Xinjiang area.Methods A total of 621 patients with IDC from January 2013 to January 2014 was classified into Luminal A type,Luminal B type,HER-2 overexpression type and Basal-like type,different molecular subtypes according to the estrogen receptor(ER),progesterone receptor(PR),epidermal growth factor receptor-2(HER-2)and Ki-67,and compared the statistics combining with the clinical pathological characteristics of IDC.Results The result showed that Luminal B type accounted for 53.1%,Luminal A type,HER-2 overexpression type and Basal-like type accounted for 14.5%,15.9%,16.4%,respectively.There were significant differences between the molecular subtypes and tumor size,histological grade,tumor pathological stage,the expression of ER,PR and HER-2(P＜0.05 for all).There were no correlations between the molecular subtypes and age,as well as lymph node metastasis(P＞0.05).Conclusion There is a close relationship between invasive ductal carcinoma of different molecular subtypes and clinical pathological characteristics.The molecular subtypes are beneficial to treatment guidelines for clinical individual.