Abstract: To explore the clinic characters,treatments and prognosis of patients with primary bone lymphoma(PLB).The clinical symptoms,signs,X-ray features,pathological morphology,immunophenotype and treatment of 7 patients with PLB were analyzed retrospectively and the pertinent literatures were reviewed.The Results showed that the main complains of 7 cases of PBL were local pain.The CT showed osteolytic bone destruction and soft tissue swelling.There were 3 cases of diffuse large B cell lymphoma,1 case of Burkitt-type lymphoma,1 case of periferal T-cell lymphoma,1 case of anaplastic large cell lymphoma,and 1 case of Hodgkins lymphoma.2 patients presented with stage Ⅰ,4 with stage Ⅱ,and 1 with stage 3.The therapeutic procedure includes local radiotherapy combined with chemotherapy and targeted therapy.The clinical presentation of PLB is not special.The diagnosis and identification of histological type of PLB should be established by histopathological and immunohistochemistry examinations.Early diagnosis and active therapy could improve the prognosis of PLB.Combination therapy including radiotherapy and chemotherapy is the optimal treatment for PLB.

Key words: Bone tumor, Primary lymphoma of bone, Diagnosis, Treatment