肿瘤免疫抑制微环境对肿瘤免疫治疗作用的研究进展

doi:10.11904/j.issn.1002-3070.2016.02.016

Abstract

Abstract: Immunosuppressive tumor microenvironment is a part of the tumor microenvironment that plays an immunosuppressive function.It consists of suppressor cells and inhibitory cytokines.In recent years,because of its important role in tumor immunity,CAR-T and PD-1/PD-L1 signal pathway has become a hot topic of immunotherapy,which can suppress immune through different mechanisms to promote tumor progression.Therefore,taking more effective anti-tumor therapies against the above mechanisms is possible to rescue the progress of tumor.In this article,the influence of immunosuppression microenvironment in CAR-T cell therapy and PD-1/PD-L1 signaling pathway in the anti-tumor process is reviewed.

Key words: Immunosuppressive microenvironment, Immunotherapy, Chimeric antigen receptor T cell, Programmed death 1, Programmed death 1 ligand

CLC Number:

R730.3

ZHANG Rui, WANG Zhiyu, WEN Xiaoting, ZHAO Hui. Study progresses of tumor immunosuppressive microenvironment in tumor immunotherapy[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(2): 167-171.

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Study progresses of tumor immunosuppressive microenvironment in tumor immunotherapy

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