抗癌新药NSC319726对卵巢癌基因表达影响的研究

doi:10.11904/j.issn.1002-3070.2016.04.009

Abstract

Abstract: Objective To study the effects of anti-cancer drug NSC319726 on the gene expression of ovarian cancer.Methods The data that NSC319726 acted on the ovarian cancer cell lines TOV112D was downloaded from the GEO database and then the bioinformatical analysis was conducted.Results NSC319726 increased 246 genes including MMP3,CXCR4 et al and decreased 198 genes such as PBX1 in ovarian cancer cell lines.GO analysis indicated that six GO items were related to metabolism.Pathway analysis revealed that NSC319726 could affect the circadian clock and MMP signaling pathway.Conclusion NSC319726 could affect the expression of multiple functional genes in ovarian cancer cell lines and might be a potential drug targeting to the precursor-B cell acute lymphoblastic leukemia.Meanwhile,it should be noted that NSC319726 may have effects on the tumor metastasis and human sleep.Therefore,further research needs to be conducted before the clinical use.

Key words: NSC319726, Ovarian cancer, Bioinformatic analysis, GO analysis, MMP signaling pathway

CLC Number:

R737.31

DENG Yanhong ,LE Xiu ,GAO Wenchao. The effects of anti-cancer drug NSC319726 on the gene expression of ovarian cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(4): 332-338.

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The effects of anti-cancer drug NSC319726 on the gene expression of ovarian cancer

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