Abstract: Objective To analyze the relationship between Arg-1 expression and the clinical pathological factors,proliferation and prognosis value in patients with colorectal cancer.Methods The expression of Arg-1 was observed in normal tissues,chronic inflammatory tissues,and adenomas inflammatory carcinoma tissues of mice.At the same time,Arg-1 expression was observed in human colorectal cancer adjacent tissues,inflamed tissues and colorectal cancer tissues.Arg-1 expressed in 20 cases colorectal inflammation-cancer model in mice.Arg-1 expressed in 20 normal colorectal tissues.Fiftheen colitis tissues and 110 colorectal cancer tissues were examined by Immunohistochemistry.Statistical analysis was used to analyze the changes of Arg-1 expression in different groups of mice and human colon tissue cases.Results Arg-1 protein expression in normal tissues of mice was gradually increased in colon,chronic inflammatory tissues,adenomas,inflammatory carcinoma,with statistical significances(P<0.05).Arg-1 expression in para-carcinoma tissue,colitis tissues,colorectal cancer tissues was gradually increased with statistical significance(P<0.05).Conclusion Arg-1 protein is associated with colorectal cancer TNM stage.Arg-1 protein may be involved in occurrence and development process of inflammation-associated colon tumor and may be a candidate of proliferated and prognostic biomarker in patients with colorectal cancer.

Key words: Arginase-1, Adenomas, Colorectal cancer