5-氨基酮戊酸光动力疗法联合重组人干扰素α2b软膏治疗老年患者表浅基底细胞癌的临床观察

doi:10.11904/j.issn.1002-3070.2016.05.003

Abstract

Abstract: Objective To evaluate the therapeutic effect of 5-aminolevulinic acid mediated photodynamic therapy(ALA-PDT)in combination with recombinant human interferon alpha 2b ointment on superficial basal cell carcinoma(BCC)in elderly.Methods A total of 143 elderly patients with superficial BCC was randomly divided into PDT group(n=72 cases)and the surgical group(n=71 cases).The patients in the two groups were given the ALA-PDT in combination with IFN-α2b and routine surgical treatment respectively.The efficacy after treatment was observed according to surgical wound area,lesion area,recurrence and security during 1 year follow-up.Results The Results displayed the complete remission rate of lesion in the PDT group was significantly higher than that in the surgical group(81.94% vs.57.75%,P＜0.05)after treatment,and the total effective rate of BCC was also higher than that in the surgical group,but no significant difference was identified in the two groups(91.66% vs.81.73%,P＞ 0.05).During 1 year follow-up after treatment,the Results showed the rate of recurrence in the PDT group was significantly lower than that in the surgical group(9.72% vs.22.54%,P＜0.05).Moreover,the mean wound area,the lesion area in the PDT group after treatment were also significantly smaller than that in the surgical group(P＜0.05).Conclusion ALA-PDT in combination with IFN is an effective method with lower recurrence and minor trauma in the treatment of superficial basal cell carcinoma.

Key words: 5-Aminolevulinic acid, Photodynamic therapy, Interferon, Superficial basal cell carcinoma

CLC Number:

R739.5

ZHOU Junmin, DAI Shaochun, ZHOU Sen. Effect of 5-aminolevulinic acid mediated photodynamic therapy in combination with recombinant human interferon alpha 2b ointment on basal cell carcinoma in elderly[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(5): 396-399.

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Effect of 5-aminolevulinic acid mediated photodynamic therapy in combination with recombinant human interferon alpha 2b ointment on basal cell carcinoma in elderly

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