LEEP术联合干扰素及重组人白介素-2对宫颈上皮内瘤变伴高危型HPV的疗效

doi:10.11904/j.issn.1002-3070.2015.03.004

Abstract

Abstract:

Objective To observe the therapeutic effect of cervical intraepithelial neoplasia Ⅱ(CIN Ⅱ)associated high risk HPV with LEEP combined interferon and recombinant human interleukin-2.Methods One hundred and sixty patients with CIN Ⅱ were selected during Feb.2012 and Feb.2013.The patients were randomly divided into four groups(40 patients in each group):the control group(LEEP),group A(LEEP united with interferon),group B(LEEP united with recombinant human interleukin-2)and group C(LEEP united with interferon and recombinant human interleukin-2).TCT,colposcope examination and HPV were reviewed,and the curative effects,postoperative complications and negative conversion rate of HPV-DNA were compared after three and six months of the treatment.Results The cure rate and negative conversion rate of HPV-DNA in group C were 92.5% and 95%,which were significantly higher than others groups(P＜0.05)after six months of treatment.The time of wound healing,duration of vaginal discharge and bleeding time in group C were also shorter than others groups(P＜0.05).Conclusion The therapeutic effect of LEEP combined with interferon and recombinant human interleukin-2 is superior to LEEP and LEEP united interferon or interleukin-2,which is not only shorter healing time,but also fewer complications.The therapeutic method is worthy to be applied widely.

Key words: Loop electrosurgical excision procedure, Interferon, Recombinant human interleukin-2, Cervical intraepithelial neoplasia, Human papillomavirus

CLC Number:

R737.33

LI Cuishuang,PI Hong,HUANG Jin,BAI Fang. Effect of LEEP combined interferon and recombinant human interleukin-2 on CIN associated high-risk HPV[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(3): 208-211.

References

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Effect of LEEP combined interferon and recombinant human interleukin-2 on CIN associated high-risk HPV

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