Aurora-A在宫颈癌及癌前病变中的表达以及与HPV感染的相关性研究

doi:10.11904/j.issn.1002-3070.2017.06.003

Abstract

Abstract: Objective The objectives of this study were to investigate the expression of Aurora-A protein in cervical cancer and precancerous lesions,and its relationship with human papilloma virus(HPV)infection,and to analyze the role of Aurora-A in the pathogenesis of cervical cancer.Methods One hundred cases of cervical biopsy or surgical resection specimens were collected from high-risk HPV(HR-HPV)test.There were 20 cases of normal cervical tissues,20 cases of CIN grade 1(CIN1),20 cases of CIN grade 2(CIN2),20 cases of CIN grade 3(CIN3),and 20 cases of cervical squamous cell carcinoma.The expression of Aurora-A protein was detected by immunohistochemistry and the correlation between Aurora-A expression and HR-HPV infection was analyzed.Results Aurora-A was highly expressed in cervical intraepithelial neoplasia and cervical cancer(P＜0.05),and its positive expression rate increased with the degree of cervical lesions.There was a positive correlation between Aurora-A expression and cervical cancer(r=0.475,P＜0.001).There was a positive correlation between Aurora-A expression and HR-HPV infection in CIN2 and CIN3(V=0.591,P＜0.05).Conclusion Aurora-A may be associated with the development of cervical cancer.Aurora-A can be used as an important biomarker for the early diagnosis of cervical intraepithelial neoplasia or cervical cancer.It is also a potential therapeutic target for cervical cancer.

Key words: Aurora-A, Centrosome, Human papillomavirus, Cervical intraepithelial neoplasia, Cervical cancer

CLC Number:

R737.3

LEI Lei, YE Qinghua, WANG Guozeng, HUANG Xianli, WU Qianyu. Expression of Aurora-A in cervical cancer and precancerous lesions,and its correlation with HPV infection[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(6): 494-499.

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Expression of Aurora-A in cervical cancer and precancerous lesions,and its correlation with HPV infection

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