MLLT6在白血病中的研究进展

doi:10.11904/j.issn.1002-3070.2018.02.009

Abstract

Abstract: MLLT6(Myeloid/Lymphoid or mixed-lineage leukemia(Trithorax homolog,Drosophila);Translocated to,6),also known as AF17(ALL1 fused gene from chromosome 17 protein)and located in chromosome 17 long arm 2 zone 1 band(17q21),was originally isolated as a MLL partner gene in leukemia.It has been reported that MLLT6 has the function of maintaining blood pressure stability.MLLT6 synergistically promotes the development of acute myeloid leukemia(AML)as an oncogene or a gene fusion with mixed lineage leukemia(t(11;17)(q23;q21)).This article provides a comprehensive overview of the research progress of MLLT6 and MLL-MLLT6 fusion protein in leukemia.

Key words: MLLT6, MLL-MLLT6 fusion protein, Leukemia, Blood pressure homeostasis

CLC Number:

R733.7

LI Yipeng, ZHANG Xinyu, LV Hanning, SUN Lichun. Research progression of MLLT6 in leukemia[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(2): 135-139.

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Research progression of MLLT6 in leukemia

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