螺杆菌属与原发性肝癌关系的研究进展

doi:10.11904/j.issn.1002-3070.2018.03.017

Abstract

Abstract: Helicobacter is a class of genus associated with many human diseases.The existing studies have found that helicobacter infection is closely related to the occurrence and development of primary liver cancer.Not only can it promote the formation of liver cancer through inflammatory stimuli and regulation of cell cycle,but it can also enhance the invasive ability of liver cancer cells through TLR4 / MyD88 signaling pathway.This article summarizes the relationship between helicobacter infection and the occurrence and development of primary liver cancer.

Key words: Helicobacter pylori, Helicobacter hepaticus, Hepatocellular carcinoma

CLC Number:

R735.7

SHI Xiaokang, DING, Youming. Research progress on the relationship between helicobacter and primary hepatocellular carcinoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 271-274.

References

1 Torre LA,Siegel RL,Ward EM,et al.Global cancer incidence and mortality rates and trends——an Update[J].Cancer Epidemiol Biomarkers Prev,2016,25(1):16-27.
2 OzakyolA.Globalepidemiology of hepatocellular carcinoma(HCC)epidemiology[J].J Gastrointest Cancer,2017,48(3):238-240.
3 Rich NE,Yopp AC,Singal AG.et al.Medical management of hepatocellular carcinoma[J].J Oncol Pract,2017,13(6):356-364.
4 Huang J,Zagai U,Hallmans G,et al.Helicobacter pylori infection,chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition(EPIC)cohort:a nested case-control study[J].Int J Cancer,2017,140(8):1727-1735.
5 Venerito M,Vasapolli R,Rokkas T,et al.Helicobacter pylori,gastric cancer and other gastrointestinal malignancies[J].Helicobacter,2017,22(1):e12413.
6 Marshall BJ,Warren JR.Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration[J].Lancet,1984,323(8390):1311-1315.
7 Fox JG,Dewhirst FE,Tully JG,et al.Helicobacter hepaticus sp.nov.,a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice[J].Clin Microbiol,1994,32(5):1238-1245.
8 Falsafi T,ahboubi M.Helicobacter hepaticus,a new pathogenic species of the Helicobacter genus:Similarities and differences with H.pylori[J].Ira J Microbiol,2013,5(3):185-194.
9 Battles JK,Williamson JC,Pike KM,et al.Diagnostic assay for Helicobacter hepaticus based on nucleotide sequence of its 16S rRNA gene[J].J Clin Microbiol,1995,33(5):1344-1347.
10 Pellicano R,Ménard A,Rizzetto M,et al.Helicobacter,species and liver diseases:association or causation?[J].Lancet Infect Dis,2008,8(4):254-260.
11 Pirouz T,Zounubi L,Keivani H,et al.Detection of Helicobacterpylori,in paraffin-embedded specimens from patients with chronic liver diseases using the amplification method[J].Dig Dis Sci,2009,54(7):1456-1459.
12 Yang J,Ji S,Zhang Y,et al.Helicobacter hepaticus infection in primary hepatocellular carcinoma tissue[J].Singapore Me J,2013,54(8):451-457.
13 JG Fox,Y Feng,Theve EJ,et al.Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens[J].Gut,2011,1(1):88-97.
14 García A,Feng Y,Parry NM,et al.Helicobacter pylori infection does not promote hepatocellular cancer in a transgenic mouse model of hepatitis C virus pathogenesis[J].Gut,2013,4(6):577-590.
15 Armstrong H,Bording-Jorgensen M,Dijk S,et al.The complex interplay between chronic inflammation,the microbiome,and cancer:understanding disease progression and what we can do to prevent it[J].Cancers,2018,10(3):83.
16 Kleine M,Worbs T,Schrem H,et al.Helicobacter hepaticus induces an inflammatory response in primary human hepatocytes[J].PLoS One,2014,9(6):e99713.
17 Ben-Neriah Y,Karin M.Inflammation meets cancer,with NF-B as the matchmaker[J].Nature Immunology,2011,12(8):715-723.
18 Fu XT,Dai Z,Song K,et al.Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway[J].Int J Oncol,2015,46(2):587-596.
19 Snider JL,Allison C,Bellaire BH,et al.The beta1 integrin activates JNK independent of Cag A,and JNK activation is required for Helicobacter pylori CagA+/-induced motility of gastric cancer cells[J].J Biol Chem,2008,283(20):13952-13963.
20 Wang J,Wang X,Tang N,et al.Impact of Helicobacter pylori on the growth of hepatic orthotopic graft tumors in mice[J].Int J Oncol,2015,47(4):1416-1428.
21 Wang,SC.PCNA:a silent housekeeper or a potential therapeutic target?[J].Trends Pharmacol Sci,2014,35(4):178-186.
22 王若谷,陈国林.Bcl-2在肝癌和胰腺癌中的表达及意义[J].实用肿瘤学杂志,2007,21(2):161-163.
23 ItoK,Yamaoka YH,El-Zimaity H,et al.Adherence,internalization,and persistence of helicobacter pylori in hepatocytes[J].Dig Dis Sci,2008,53(9):2541-2549.
24 Ru Y,Chen XJ,Zhao ZW,et al.CyclinD1 and p57kip2 as biomarkers in differentiation,metastasis and prognosis of gastric cardia adenocarcinoma[J].Oncotarget,2017,8(43):73860-73870.
25 张春忙,彭凡洲,邓慧敏,等.肝螺杆菌对肝癌细胞侵袭能力的影响及其可能分子机制[J].现代消化及介入诊疗,2015,20(3):206-211.
26 张福星,张思宇,苏国强,等.幽门螺杆菌感染与原发性肝癌侵袭转移的关系[J].临床肿瘤学杂志,2010,15(2):123-126.
27 Desgrosellier JS,Cheresh DA.Integrins in cancer:biological implications and therapeutic opportunities[J].Nat Rev Cancer,2010,10(1):9-22.
28 Mitchell H,Katelaris P.Epidemiology,clinical impacts and current clinical management of Helicobacter pylori infection[J].Med J Aust,2016,204(10):376-380.

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Research progress on the relationship between helicobacter and primary hepatocellular carcinoma

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