Journal of Practical Oncology ›› 2021, Vol. 35 ›› Issue (2): 148-153.doi: 10.11904/j.issn.1002-3070.2021.02.009

• Clinical Application • Previous Articles     Next Articles

Research on the correlation between X-ray imaging and molecular types and histological grade of breast invasive ductal carcinoma

LIU Ke1,2,3, WANG Shenglin3   

  1. 1. Graduate School of Chengde Medical university,Chengde 067000,China;
    2. Department of Ultrasound,The First Central Hospital of Baoding City;
    3. Department of Radiology,The Affiliated Hospital of Chengde Medical University
  • Received:2020-10-14 Revised:2020-12-14 Online:2021-04-28 Published:2021-04-27

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Abstract: Objective The aim of this study was to explore the different mammographic features of breast invasive ductal carcinoma with different molecular subtypes and the correlation with histological grade. Methods The complete diagnosis and treatment data of patients hospitalized with breast tumors during the period and all received preoperative mammography to be finally diagnosed with invasive ductal carcinoma of the breast through pathological examination were collected and sorted out.Referring to the 2019 Chinese Society for Clinical Oncology Breast Cancer Diagnosis and Treatment Guidelines(CSCO BC Guidelines)recommend methods for molecular typing,the preoperative X-ray images and postoperative pathological data were retrospectively analyzed to compare the differences in X-ray images between different molecular subtype groups and the relationship with histopathological grade. Results The five groups of molecular subtypes showed significant differences in X-ray images in terms of gland type,malignant calcification,and mass characteristics(P＜0.05).Among them,the three-negative gland type was mostly scattered and fibrous(52.8%,19/36),and the proportion of malignant calcification(13.9%,5/36),blurred edges(16.3%,7/36)and astral signs(9.3%,4/36)on the edges of the tumor was significantly reduced.The five molecular subtypes had significant differences in histological grading(P＜0.01),of which the proportion of three-negative poorly differentiated group(63.9%,23/69)and the proportion of Luminal A's moderately differentiated group(97.2%,72/74)were significantly higher than the other subgroups.Multivariate logistic regression showed that X-ray images with clear tumor edges were a risk factor for the poorly differentiated group(P＜0.05). Conclusion The X-ray images of invasive ductal carcinoma of the breast can help predict its molecular classification and histological grade to a certain extent,and can provide some help for personalized diagnosis and treatment and prognostic analysis of breast cancer patients.

Key words: Breast invasive ductal carcinoma;Mammography;Molecular typing;Histological grading

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