胃肠胰神经内分泌肿瘤的免疫治疗研究进展

doi:10.11904/j.issn.1002-3070.2021.02.010

Abstract

Abstract: Advanced gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs)have limited therapeutic drugs and poor efficacy.As a promising treatment method,immunotherapy has been initially explored in GEP-NENs in recent years.Current research results show that immune checkpoint inhibitors have good anti-tumor activity and safety in GEP-NENs.The expression of PD-L1 in the primary site of different GEP-NENs is different,and it is negatively correlated with the degree of differentiation.The effect of PD-L1 expression and immune cell infiltration on the prognosis of GEP-NENs patients is still controversial.The biomarkers that can predict the benefits of immunotherapy have not yet been determined.This article reviews the research progress of immunotherapy for GEP-NENs.

Key words: Gastroenteropancreatic neuroendocrine tumors;Biomarkers;Immunotherapy;Immune checkpoint inhibitors

CLC Number:

R730.51

WANG Mengmeng, LIAN Jie, LI Hengzhen, ZHANG Yanqiao. Research progress in immunotherapy of gastrointestinal pancreatic neuroendocrine tumors[J]. Journal of Practical Oncology, 2021, 35(2): 154-159.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2021.02.010

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2021/V35/I2/154

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Research progress in immunotherapy of gastrointestinal pancreatic neuroendocrine tumors

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