内质网应激在肝癌中的作用

doi:10.11904/j.issn.1002-3070.2021.02.011

Abstract

Abstract: Endoplasmic reticulum stress(ERS)is an extremely important signal response pathway.When the ER is stressed,the survival pathway-the unfolded protein response(UPR)is first initiated,and the prolonged ERS will initiate the apoptosis pathway.At present,more and more studies have shown that liver cancer is closely related to ERS,and it has been confirmed that the tumor microenvironment of liver cancer can cause ERS.According to the dual role of ER reported in relevant literature,ERS can not only induce the transformation of liver cancer,but it also inhibits the proliferation and metastasis of liver cancer.Therefore,ERS provides the possibility of new treatment methods for liver cancer.This article reviews the research progress on the relationship between ERS and liver cancer.

Key words: Liver cancer;Endoplasmic reticulum stress;Autophagy;Apoptosis;Unfolded protein response

CLC Number:

R735.7

HU Qihui, DU Yichao, HE Kai, FU Wenguang, XIA Xianming. The role of endoplasmic reticulum stress in liver cancer[J]. Journal of Practical Oncology, 2021, 35(2): 160-164.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2021.02.011

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2021/V35/I2/160

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The role of endoplasmic reticulum stress in liver cancer

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