Notch信号通路调控肿瘤细胞凋亡机制研究进展

doi:10.11904/j.issn.1002-3070.2021.02.012

Abstract

Abstract: The abnormal expression of Notch signaling pathway in many tumor cells,due to its high background correlation,shows the role of proto-oncogene or tumor suppressor gene.When the expression of Notch signal is affected by external stimulation or intracellular signal,Notch signal can promote or inhibit tumor cell apoptosis through“crosstalk” with other cell signaling pathways or by directly regulating apoptotic proteins.This paper reviews the mechanism of Notch signaling pathway in promoting and inhibiting tumor cell apoptosis,and provides theoretical support for anti-tumor therapy of Notch signaling pathway through the different effects of Notch signaling pathway on various apoptosis pathways.

Key words: Notch signaling pathway;Tumor cell;Apoptosis;Mechanism

CLC Number:

R730.2

YIN Qi, HU Yanjian, CUI Puze, HU Yanhua. Research progress of Notch signaling pathway in regulating apoptosis of tumor cells[J]. Journal of Practical Oncology, 2021, 35(2): 165-169.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2021.02.012

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2021/V35/I2/165

References

1 Ngoi NYL,Choong C,Lee J,et al.Targeting mitochondrial apoptosis to overcome treatment resistance in cancer[J].Cancers(Basel),2020,12(3):574.
2 Prasad S,Ramachandran S,Gupta N,et al.Cancer cells stemness:a doorstep to targeted therapy[J].Biochim Biophys Acta Mol Basis Dis,2020,1866(4):165424.
3 Ghanavati R,Asadollahi P,Shapourabadi MB,et al.Inhibitory effects of Lactobacilli cocktail on HT-29 colon carcinoma cells growth and modulation of the Notch and Wnt/β-catenin signaling pathways[J].Microb Pathog,2019,139:103829.
4 Aster JC,Pear WS,Blacklow SC.The varied roles of notch in cancer[J].Annu Rev Pathol,2017,12:245-275.
5 罗干,易超,依马木买买提江·阿布拉,等.Notch信号通路在胰腺癌中的表达及其作用研究[J].实用肿瘤学杂志,2019,33(1):1-7.
6 Matsuno K.Notch signaling[J].Dev Growth Differ,2020,62(1):3.
7 Mandal R,Barrón JC,Kostova I,et al.Caspase-8:the double-edged sword[J].Biochim Biophys Acta Rev Cancer,2020,1873(2):188357.
8 Carneiro BA,El-Deiry WS.Targeting apoptosis in cancer therapy[J].Nat Rev Clin Oncol,2020,10:1038.
9 Kushwaha PP,Vardhan S,Kapewangolo P,et al.Bulbine frutescens phytochemical inhibits notch signaling pathway and induces apoptosis in triple negative and luminal breast cancer cells[J].Life Sci,2019,234:116783.
10 Abate M,Festa A,Falco M,et al.Mitochondria as playmakers of apoptosis,autophagy and senescence[J].Semin Cell Dev Biol,2020,98:139-153.
11 Goldar S,Khaniani MS,Derakhshan SM,et al.Molecular mechanisms of apoptosis and roles in cancer development and treatment[J].Asian Pac J Cancer Prev,2015,16(6):2129-2144.
12 Wang X,Gong S,Pu D,et al.Up-regulation of miR-365 promotes the apoptosis and restrains proliferation of synoviocytes through downregulation of IGF1 and the inactivation of the PI3K/AKT/mTOR pathway in mice with rheumatoid arthritis[J].Int Immunopharmacol,2020,79:106067.
13 Marquard FE,Jücker M.PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer[J].Biochem Pharmacol,2020,172:113729.
14 Gutierrez A,Look AT.NOTCH and PI3K-AKT pathways intertwined[J].Cancer Cell,2007,12(5):411-413.
15 Lewis HD,Leveridge M,Strack PR,et al.Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling[J].Chem Biol,2007,14(2):209-219.
16 O'Neil J,Grim J,Strack P,et al.FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors[J].J Exp Med,2007,204(8):1813-1824.
17 Liu X,Zhao P,Wang X,et al.Triptolide induces glioma cell autophagy and apoptosis via upregulating the ROS/JNK and downregulating the Akt/mTOR signaling pathways[J].Front Oncol,2019,9:387.
18 Soleimani A,Rahmani F,Ferns GA,et al.Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer[J].Gene,2020,726:144132.
19 Oswald F,Liptay S,Adler G,et al.NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa[J].Mol Cell Biol,1998,18(4):2077-2088.
20 Cheng P,Zlobin A,Volgina V,et al.Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells[J].J Immunol,2001,167(8):4458-4467.
21 Wang J,Shelly L,Miele L,et al.Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain[J].J Immunol,2001,167(1):289-295.
22 Li L,Zhao F,Lu J,et al.Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation[J].PLoS One,2014,9(4):e95912.
23 Shin HM,Minter LM,Cho OH,et al.Notch1 augments NF-kappaB activity by facilitating its nuclear retention[J].EMBO J,2006,25(1):129-138.
24 Wu W,Nie L,Zhang L,et al.The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells[J].Cell Mol Biol Lett,2018,23(1):37.
25 Song LL,Peng Y,Yun J,et al.Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells[J].Oncogene,2008,27(44):5833-5844.
26 Blandino G,Valenti F,Sacconi A,et al.Wild type-and mutant p53 proteins in mitochondrial dysfunction:emerging insights in cancer disease[J].Semin Cell Dev Biol,2020,98:105-117.
27 Beverly LJ,Felsher DW,Capobianco AJ.Suppression of p53 by Notch in lymphomagenesis:implications for initiation and regression[J].Cancer Res,2005,65(16):7159-7168.
28 Kim SB,Chae GW,Lee J,et al.Activated Notch1 interacts with p53 to inhibit its phosphorylation and transactivation[J].Cell Death Differ,2007,14(5):982-991.
29 Boggs K,Henderson B,Reisman D.RBP-Jkappa binds to and represses transcription of the p53 tumor suppressor gene[J].Cell Biol Int,2009,33(3):318-324.
30 Qi R,An H,Yu Y,et al.Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis[J].Cancer Res,2003,63(23):8323-8329.
31 Wang C,Qi R,Li N,et al.Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression[J].J Biol Chem,2009,284(24):16183-16190.
32 Talora C,Cialfi S,Segatto O,et al.Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways[J].Exp Cell Res,2005,305(2):343-354.
33 Warren CFA,Wong-Brown MW,Bowden NA.BCL-2 family isoforms in apoptosis and cancer[J].Cell Death Dis,2019,10(3):177.
34 Khan F,Singh VK,Saeed M,et al.Carvacrol induced program cell death and cell cycle arrest in androgen-independent human prostate cancer cells via inhibition of notch signaling[J].Anticancer Agents Med Chem,2019,19(13):1588-1608.
35 Sun Z,Zhou C,Liu F,et al.Inhibition of breast cancer cell survival by Xanthohumol via modulation of the Notch signaling pathway in vivo and in vitro[J].Oncol Lett,2018,15(1):908-916.
36 Cao H,Hu Y,Wang P,et al.Down-regulation of Notch receptor signaling pathway induces caspase-dependent and caspase-independent apoptosis in lung squamous cell carcinoma cells[J].APMIS,2012,120(6):441-450.
37 Bessette B,Durand K,Giraud S,et al.Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75(NTR)in a glioblastoma cell line[J].Exp Ther Med,2012,3(5):873-877.
38 Shi FT,Yu M,Zloty D,et al.Notch signaling is significantly suppressed in basal cell carcinomas and activation induces basal cell carcinoma cell apoptosis[J].Mol Med Rep,2017,15(4):1441-1454.
39 Portanova P,Notaro A,Pellerito O,et al.Notch inhibition restores TRAIL-mediated apoptosis via AP1-dependent upregulation of DR4 and DR5 TRAIL receptors in MDA-MB-231 breast cancer cells[J].Int J Oncol,2013,43(1):121-130.

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[2]	LI Hongwei,JIANG Xiaofeng,CHEN Song,BIE Yifei,DU Yong. A case of huge scar squamous cell carcinoma with skull and dural invasion [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(4): 337-339.
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[5]	SHEN Meiying, PANG Da. Regulation of long non-coding RNAs in the tumor microenvironment [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(1): 73-76.
[6]	TANG Qiulin,BI Feng. Identification of guanine nucleotide exchange factor ARHGEF 10 and its relationship with tumor malignant phenotype [J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(6): 481-488.
[7]	QIN Qi,XU Yang,ZHAO Hong,ZHANG Qingyuan. Research progress of tumor-associated neutrophils [J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(4): 367-370.
[8]	LIU Jiaqi,LIU Yaohua,CHEN Xin,ZHAO Shiguang. Research progress of CD4⁺CD25⁺Foxp3⁺ regulatory T cells in tumor immunosuppressive microenvironment [J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(6): 555-559.
[9]	QI Feng,TAI Sheng. Research progresses of tumor inhibiting protein p33ING1b in the tumors of digestive system [J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(3): 254-258.
[10]	LI Ruyi,LU Jianbo. The gene expression profile in the pathological diagnosis and differential diagnosis of tumors [J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(3): 275-278.
[11]	ZHAO Jia,SONG Yulin,ZHANG Yuxia,SUN Binzhou,WANG Jing. The research progression on the relationship between TRPS1 and tumors [J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(1): 78-81.
[12]	XU Gangzhu,LI Wen,ZHANG Peng,WANG Hui,SHENG Xudong,WANG Maode. Effect of CEACAM1 gene RNAi on angiogenesis of glioma in vitro [J]. PRACTICAL ONCOLOGY JOURNAL, 2014, 28(6): 514-518.
[13]	JIANG Yang,GENG Jingshu. Snail regulate tumor cell epithelial-to-myofibroblast transition related signaling pathways [J]. PRACTICAL ONCOLOGY JOURNAL, 2014, 28(6): 573-576.
[14]	MA RuiJin,YANG Yu. The research development of PI3K/AKT/mTOR signaling pathway in HER2 resistance for the treatment of breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2014, 28(4): 360-363.
[15]	ZHANG Baihong,YUE Hongyun. The origins of tumors:local or whole? [J]. PRACTICAL ONCOLOGY JOURNAL, 2013, 27(5): 444-446.

Research progress of Notch signaling pathway in regulating apoptosis of tumor cells

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