eccDNA在癌症中的研究进展

doi:10.11904/j.issn.1002-3070.2022.03.011

Abstract

Abstract: The DNA of eukaryotic cells mainly exists on the chromosomes,but in fact there is also DNA outside chromosomes,which is a special kind of circular DNA(extrachromosomal circular DNA,eccDNA).Several types of eccDNA have been discovered,including small polydispersed DNA(spcDNA),telomere loops,extrasomal rDNA loops and microDNA(miDNA),etc.eccDNA is separated or detached from the genome,coexists with the chromosomal DNA,and participates in pathological or physiological processes of the body in a special way.This paper summarizes the classification,formation mechanism,expression and role formation of eccDNA in cancer.

Key words: extrachromosomal circular DNA, Cancer, Drug resistance

CLC Number:

R730.2

YU Chengping, CUI Yongkang, LI Linqiang. Research progress of eccDNA in cancer[J]. Journal of Practical Oncology, 2022, 36(3): 255-258.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2022.03.011

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2022/V36/I3/255

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Research progress of eccDNA in cancer

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