JMJD2B蛋白结构功能及在恶性肿瘤发生发展中的研究进展

doi:10.11904/j.issn.1002-3070.2018.03.012

Abstract

Abstract: The JMJD family is an important group of histone demethylase.JMJD2B belongs to one of its family members,and is a JMJD containing a JmjC domain.It mainly regulates chromatin structure,transcription and cell appearance.Recent studies from domestic and foreign have demonstrated that JMJD2B protein is high expressed in human malignant tumors,such as liver cancer,gastric cancer,breast cancer,kidney cancer,and skin cancer.Moreover,it also shows that JMJD2B is involved in the occurrence,development,migration,infiltration,and proliferation of malignant tumors.

Key words: JMJD2B protein, Structure and function, Malignant tumor

CLC Number:

R730.23

HOU Siyu, CHEN Xiuwei. The structure and function of JMJD2B protein and its progress in the development of malignant tumor[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 250-253.

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The structure and function of JMJD2B protein and its progress in the development of malignant tumor

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