Abstract: Objective The aim of this study was to investigate the correlation among systemic immune-inflammation indexes(SII),neutrophils to lymphocytes ratio(NLR),platelets to lymphocytes ratio(PLR),prognosis of patients with resectable gastric cancer,and their clinical significance. Methods Clinicopathological data of 226 patients with gastric cancer treated in the Affiliated Cancer Hospital of Harbin Medical University from October 2013 to February 2015 were retrospectively analyzed.The prognostic values of SII,NLR and PLR in patients with resectable gastric cancer were evaluated and compared. Results The SII,NLR and PLR of the gastric cancer group were significantly higher than those of the healthy control group,and the differences were statistically significant(P＜0.05).Multivariate Cox regression analysis showed that high SII(HR=2.947,95% CI:1.345~6.454,P=0.007),high NLR(HR=2.876,95% CI:1.445~5.724,P=0.003),high T staging(HR=5.885,95% CI:1.641~21.099,P=0.007)and presence of distant metastasis(HR=3.010,95% CI:1.472~6.154,P=0.003)were independent risk factors affecting the prognosis of patients with resectable gastric cancer.The area under the ROC curve of SII predicting the outcome of resectable gastric cancer patients was 0.840,the sensitivity was 86.6%,and the specificity was 68.0%,which was higher than NLR,PLR and CA199,and the difference was statistically significant(P＜0.05). Conclusion SII is better than NLR and PLR in evaluating the survival outcomes of patients with resectable gastric cancer.

Key words: Gastric cancer, Systemic immune-inflammation indexes, Neutrophils to lymphocytes ratio, Platelets to lymphocytes ratio, Prognosis