肝细胞癌相关RNA结合蛋白研究进展

doi:10.11904/j.issn.1002-3070.2021.06.018

Abstract

Abstract: The incidence and mortality of primary liver cancer in China have been among the top five malignant tumors for many years,the recurrence rate is high and the prognosis is poor.In recent years,with the continuous in-depth research on gene expression,carcinogenesis and development,the scope of exploration is not limited to the study of coding RNA.Many non-coding RNAs have been gradually attracted the attention of researchers.RNA binding proteins,as the“transportation hub”involved in the regulation of these RNAs,play an important role.This article will describe the research progress of RNA-binding proteins related to hepatocellular carcinoma one by one,in order to provide valuable references and ideas for future research.

Key words: Hepatocellular carcinoma, RNA binding proteins, Research progress

CLC Number:

R735.7

ZHAO Haoran, LI Man, ZHANG Yubao. Research progress of hepatocellular carcinoma-related RNA binding protein[J]. Journal of Practical Oncology, 2021, 35(6): 576-579.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2021.06.018

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2021/V35/I6/576

References

1 Bray F,Ferlay J,Soerjomataram I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.
2 《原发性肝癌诊疗规范(年版)》编写专家委员会.原发性肝癌诊疗规范(2019年版)[J].中国临床医学,2020,27(1):140-156.
3Eberhardt W,Nasrullah U,Haeussler K.Inhibition of caspase-2 translation by the mRNA binding protein HuR:a novel path of therapy resistance in colon carcinoma cells?[J].Cells,2019,8(8):797.
4 Schultz CW,Preet R,Dhir T,et al.Understanding and targeting the disease‐related RNA binding protein human antigen R(HuR)[J].Wiley Interdiscip Rev RNA,2020,11(3):e1581.
5 Liu R,Wu K,Li Y,et al.Human antigen R:a potential therapeutic target for liver diseases[J].Pharmacol Res,2020,155:104684.
6 Sulima SO,Kampen KR,De Keersmaecker K.Cancer biogenesis in ribosomopathies[J].Cells,2019,8(3):229.
7 Madru C,Lebaron S,Blaud M,et al.Chaperoning 5S RNA assembly[J].Genes Dev,2015,29(13):1432-1446.
8 Zhao L,Cao J,Hu K,et al.RNA-binding protein RPS3 contributes to hepatocarcinogenesis by post-transcriptionally up-regulating SIRT1[J].Nucleic Acids Res,2019,47(4):2011-2028.
9 Aoi Y,Smith ER,Shah AP,et al.NELF regulates a promoter-proximal step distinct from RNA Pol II pause-release[J].Mol Cell,2020,78:261-274.
10 Bahat A,Lahav O,Plotnikov A,et al.Targeting Spt5-Pol II by small-molecule inhibitors uncouples distinct activities and reveals additional regulatory roles[J].Mol Cell,2019,76(4):617-631.
11 Han L,Zan Y,Huang C,et al.NELFE promoted pancreatic cancer metastasis and the epithelial to mesenchymal transition by decreasing the stabilization of NDRG2 mRNA[J].Int J Oncol,2019,55(6):1313-1323.
12 Dang H,Takai A,Forgues M,et al.Oncogenic activation of the RNA binding protein NELFE and MYC signaling in hepatocellular carcinoma[J].Cancer cell,2017,32(1):101-114.
13 Vos SM,Pöllmann D,Caizzi L,et al.Architecture and RNA binding of the human negative elongation factor[J].Elife,2016,5:e14981.
14 Hao J,Wang Z,Wang Y,et al.Eukaryotic initiation factor 3C silencing inhibits cell proliferation and promotes apoptosis in human glioma[J].Oncol Rep,2015,33(6):2954-2962.
15 Li T,Li S,Chen D,et al.Transcriptomic analyses of RNA-binding proteins reveal eIF3c promotes cell proliferation in hepatocellular carcinoma[J].Cancer Sci,2017,108(5):877-885.
16 Yisraeli JK.VICKZ proteins:a multi-talented family of regulatory RNA-binding proteins[J].Biol Cell,2005,97(1):87-96.
17 Zhou X,Zhang CZ,Lu SX,et al.miR-625 suppresses tumour migration and invasion by targeting IGF2BP1 in hepatocellular carcinoma[J].Oncogene,2015,34(8):965-977.
18 Ye J,Liang R,Bai T,et al.RBM38 plays a tumor-suppressor role via stabilizing the p53-mdm2 loop function in hepatocellular carcinoma[J].J Exp Clin Cancer Res,2018,37(1):212.
19 Xu E,Zhang J,Chen X.MDM2 expression is repressed by the RNA-binding protein RNPC1 via mRNA stability[J].Oncogene,2013,32(17):2169-2178.
20 Zou C, Wan Y,He L,et al.RBM38 in cancer:role and mechanism[J].Cell Mol Life Sci,2021:78(1):117-128.
21 Qian K,Li M,Wang J,et al.Structural basis for mRNA recognition by human RBM38[J].Biochem J,2020,477(1):161-172.
22 Lucchesi CA,Zhang J,Ma B,et al.Disruption of the Rbm38-eIF4E complex with a synthetic peptide Pep8 increases p53 expression[J].Cancer Res,2019,79(4):807-818.
23 Ding C,Cheng S,Yang Z,et al.Long non-coding RNA HOTAIR promotes cell migration and invasion via down-regulation of RNA binding motif protein 38 in hepatocellular carcinoma cells[J].Int J Mol Sci,2014,15(3):4060-4076.
24 Yan B,Peng Z,Xing C.SORBS2,mediated by MEF2D,suppresses the metastasis of human hepatocellular carcinoma by inhibitiing the c-Abl-ERK signaling pathway[J].Am J Cancer Res,2019,9(12):2706-2718.
25 Su L,Luo Y,Yang Z,et al.MEF2D transduces microenvironment stimuli to ZEB1 to promote epithelial-mesenchymal transition and metastasis in colorectal cancer[J].Cancer Res,2016,76(17):5054-5067.
26 Zhang C,Yu Y,Ma L,et al.Histamine H3 receptor promotes cell survival via regulating PKA/CREB/CDKN1A signal pathway in hepatocellular carcinoma[J].Onco Targets Ther,2020,13:3765.
27 Wu BH,Chen H,Cai CM,et al.Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A 686[J].Oncotarget,2016,7(6):6847-6863.

[1]	LIU Fei, SUI Hong. Research progress in molecular classification of liver cancer based on tumor immunological microenvironment [J]. Journal of Practical Oncology, 2021, 35(6): 557-561.
[2]	JI Lei, JI Daolin, BAO Dongdong, TAN Gang. The latest research progress of long non-coding RNA in sorafenib resistance of hepatocellular carcinoma [J]. Journal of Practical Oncology, 2021, 35(6): 562-567.
[3]	HE Ling, YAO Kecheng. Glycosylphosphatidylinositol transamidase and hepatocellular carcinoma [J]. Journal of Practical Oncology, 2021, 35(5): 458-461.
[4]	ZHOU Jian,CHEN Xuejian,WANG Wei,LI Ning,SUN Zhenyu,XU Lishan. The effect of silencing PRMT5 gene in biological behavior of human hepatocellular carcinoma cells [J]. Journal of Practical Oncology, 2020, 34(3): 208-213.
[5]	ZHANG Congyi, CUI Yifeng, LI Baobao, LIU Lianxin. Expression of cell division cycle 7 protein in hepatocellular carcinoma tissues and its effect on proliferation and invasion of hepatocellular carcinoma cells [J]. Journal of Practical Oncology, 2020, 34(2): 150-155.
[6]	GUO Yongdong, JIN Jing, LI Limin, HE Yutong. Progress in differentiation of non-protein-encoding RNA(DANCR)in common malignant tumors [J]. Journal of Practical Oncology, 2020, 34(1): 69-73.
[7]	CHEN Ziyin, BAI Yanchun, CAO Yangsen, LI Jian, XU Lili, ZHAO Qiushuang, WANG Yang. Dosimetry advantage of respiratory gating in the treatment of hepatocellular carcinoma with large segmentation [J]. Journal of Practical Oncology, 2019, 33(6): 536-539.
[8]	LI Susu, ZHOU Chunxiang. Two-way regulation of NKT cells on immune response to liver cancer [J]. Journal of Practical Oncology, 2019, 33(6): 540-543.
[9]	QU Yanfei, LIU Chao, WANG Bojun, FANG Lin, ZHANG Yanqiao. Expression of CSN6 gene in hepatocellular carcinoma tissues and its clinical significance [J]. Journal of Practical Oncology, 2019, 33(4): 328-333.
[10]	HE Wei, MU Qiming, WANG Gang, WAN Bo, LIAO Bo, YANG Juan. Expression of TACC3 and p53 protein in primary liver cancer and its clinical significance [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 420-425.
[11]	SHI Xiaokang, DING, Youming. Research progress on the relationship between helicobacter and primary hepatocellular carcinoma [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 271-274.
[12]	WEN Juanjuan, QU Bing, LIU Chao. Clinical significance of antithrombin Ⅲ gene expression in hepatocellular carcinoma tissues [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(2): 117-121.
[13]	ZHAO Lingyun, QI Lunan, YOU Xuemei. Research progress of heat shock protein 70 in hepatocellular carcinoma [J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(6): 528-532.
[14]	ZHOU Chunfang,ZHAO Shanshan,SUN Zequn,WU Jun,ZHA Huolong,YUAN Yahong. Acid conditions induces EMT of hepatocellular carcinoma HepG2 cells [J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(3): 199-204.
[15]	ZHAO Menglei. Effects of lycopene on the proliferation and apoptosis in human hepatocellular carcinoma HepG2 cells [J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(3): 211-216.

Research progress of hepatocellular carcinoma-related RNA binding protein

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments