Abstract: Objective The aim of this study was to explore the predictive value of nutritional risk index(NRI)for postoperative complications and prognosis in patients with resectable hepatocellular carcinoma(HCC). Methods The clinical data of 137 patients with HCC after radical hepatectomy admitted to the First Affiliated Hospital of Harbin Medical University from January 2016 to December 2017 were retrospectively analyzed.The receiver operating characteristic(ROC)curve was used to evaluate the therapeutic effect of NRI after hepatectomy,and the optimal diagnosis point was determined to be 99.The patients were divided into the high NRI group(NRI≥99)and the low NRI group(NRI＜99).The independent risk factors of postoperative complications were analyzed and the postoperative complications were compared between the two groups.The relationship between NRI and disease-free survival(DFS)or overall survival(OS)was analyzed in HCC patients. Results Compared with patients in the high NRI group,HCC patients in the low NRI group had a higher incidence of postoperative complications and were more prone to serious complications(P＜0.05).The results of multivariate logistic analysis showed that NRI,CNLC stage and surgical time were independent risk factors for postoperative complications in HCC patients(P＜0.05).The results of multivariate Cox regression analysis showed that NRI,age,tumor size and CNLC stage were independent predictors of DFS(P＜0.05).NRI,tumor size,CNLC stage,and history of hypertension were independent predictors of OS(P＜0.05). Conclusion Low NRI is an independent risk factor for postoperative complications in HCC patients,and NRI has an independent predictive value for the prognosis of HCC patients,which is positively correlated with DFS and OS of patients.

Key words: Nutritional risk index, Hepatocellular carcinoma, Postoperative complications, Prognosis