单细胞测序技术在乳腺癌中的研究进展

doi:10.11904/j.issn.1002-3070.2023.03.016

Abstract

Abstract: Breast cancer is a malignant tumor with the highest incidence among women in the world,and it is also one of the main causes of cancer death among women.More and more studies have shown that breast cancer is a highly heterogeneous disease.Traditional high-throughput sequencing technology provides an important reference for the occurrence and development,accurate typing,diagnosis and treatment of breast cancer,but it still has limitations and cannot reveal the heterogeneity within the tumor.Compared with traditional sequencing technology,single-cell sequencing technology has been greatly improved in the sensitivity,accuracy and efficiency.This technology can analyze the molecular biological information of single cells in complex mixed cells,and show great advantages in tumor heterogeneity.It includes analyzing the transcriptome map of breast cancer from the single-cell level,exploring the heterogeneity of breast cancer microenvironment,exploring the mechanism of breast cancer metastasis and drug resistance,and exploring the clonal heterogeneity and evolution of breast cancer.This article reviews the recent research progress of single-cell sequencing technology for breast cancer in recent years,aiming to provide a theoretical reference for single-cell sequencing technology in breast cancer.

Key words: Single cell sequencing, Breast cancer, Heterogeneous

CLC Number:

R737.9

YANG Shuai, WANG Xinheng, WU Jiale, FU Zitong, WEI Bo, YANG Lingbing, XU Shouping. Research progress of single-cell sequencing technology in breast cancer[J]. Journal of Practical Oncology, 2023, 37(3): 287-292.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2023.03.016

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Research progress of single-cell sequencing technology in breast cancer

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