MiRNA在肝癌发生发展中的表达及作用机制

doi:10.11904/j.issn.1002-3070.2025.01.009

Abstract

Abstract: MiRNA,as a class of short non-coding RNA molecules,plays an important role in the post-transcriptional regulation of gene expression.miRNAs regulate gene expression by targeting specific mRNA sequences,thereby affecting various cellular biological behaviors,including proliferation,apoptosis,migration,and invasion.In recent years,it has been found that miRNA may play an important role in the occurrence and development of hepatocellular carcinoma.This article provides a review of the research progress on the association between miRNA and the occurrence and development of hepatocellular carcinoma.

Key words: Liver cancer, microRNA, Treatment, Apoptosis, Invasion

CLC Number:

R735.7

ZHANG Beining, WANG Jiangye, MA Kewen, SUN Guoliang, YAN Kesong, ZHENG Ninggang. Expression and mechanism of miRNA in the occurrence and development of hepatocellular carcinoma[J]. Journal of Practical Oncology, 2025, 39(1): 61-66.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2025.01.009

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2025/V39/I1/61

References

1 Gao YX,Yang TW,Yin JM,et al.Progress and prospects of biomarkers in primary liver cancer[J].Int J Oncol,2020,57(1):54-66.
2 Mori A,Arimoto A,Hamaguchi Y,et al.Risk factors and outcome of portal vein thrombosis after laparoscopic and open hepatectomy for primary liver cancer:a single-center experience[J].World J Surg,2020,44(9):3093-3099.
3 Xu J,Yang X,Hu X,et al.Multilevel thoracic paravertebral block using ropivacaine with/without dexmedetomidine in video-assisted thoracoscopic surgery[J].J Cardiothorac Vasc Anesth,2018,32(1):318-324.
4 Hwang H,Chang HR,Baek D.Determinants of functional microRNA targeting[J].Mol Cells,2023,46(1):21-32.
5 Wang H,Shi J,Wang J,et al.MicroRNA-378:an important player in cardiovascular diseases[J].Mol Med Rep,2023,28(3):172.
6 Liu Y,Yang Y,Wang X,et al.Function of microRNA-124 in the pathogenesis of cancer[J].Int J Oncol,2024,64(1):6.
7 Xia Q,Liu G,Lin W,et al.microRNA-2117 negatively regulates liver cancer stem cells expansion and chemoresistance via targeting SOX2[J].Mol Carcinog,2025,64(1):33-43.
8 Rankovi＇c B,Hauptman N.Circulating microRNA panels for detection of liver cancers and liver-metastasizing primary cancers[J].Int J Mol Sci,2023,24(20):15451.
9 Yuan X,Wen Y,Shi Q,et al.MicroRNA-148a-3p suppresses the glycolysis and cell proliferation by targeting transmembrane protein 54 in liver cancer[J].Biochem Biophys Res Commun,2024,695:149424.
10 Lai EC.Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation[J].Nat Genet,2002,30(4):363-364.
11 Huang Y,Shen XJ,Zou Q,et al.Biological functions of microRNAs:a review[J].J Physiol Biochem,2011,67(1):129-139.
12 陈泽山,文彬,丘佩容,等.microRNA-122在肝病发生发展及诊断中的作用[J].临床肝胆病杂志,2021,37(7):1724-1728.
13 牛虹,田同德,唐静雯,等.微小RNA-148a-3p靶向调控MAP3K9表达及对胃癌细胞增殖和凋亡的影响[J].临床肿瘤学杂志,2019,24(2):108-112.
14 梅孝臣,王娟,王磊,等.微小RNA-597靶向Rab23对肝癌细胞增殖、周期和凋亡的影响[J].中华实验外科杂志,2022,39(2):265-268.
15 Hong CJ,Park H,Yu SW.Autophagy for the quality control of adult hippocampal neural stem cells[J].Brain Res,2016,1649(Pt B):166-172.
16 Zeng H,Zheng J,Wen S,et al.MicroRNA-339 inhibits human hepatocellular carcinoma proliferation and invasion via targeting ZNF689[J].Drug Des Devel Ther,2019,13:435-445.
17 Zhang TQ,Su QQ,Huang XY,et al.Micro RNA-4651 serves as a potential biomarker for prognosis when selecting hepatocellular carcinoma patients for postoperative adjuvant transarterial chemoembolization therapy[J].Hepatol Commun,2018,2(10):1259-1273.
18 Li Y,Wang X,Li Z,et al.MicroRNA-4651 represses hepatocellular carcinoma cell growth and facilitates apoptosis via targeting FOXP4[J].Biosci Rep,40(6):BSR20194011.
19 Wang H,Lin X,Liu E,et al.MicroRNA-33b regulates hepatocellular carcinoma cell proliferation,apoptosis,and mobility via targeting Fli-1-mediated Notch1 pathway[J].J Cell Physiol,2020,235(10):7635-7644.
20 Xu J,Liu F,Xia Z,et al.MiR-3188 regulates the proliferation and apoptosis of hepatocellular carcinoma cells by targeting CXCL14[J].Biomark Med,2021,15(17):1611-1621.
21 Wang L,Mo H,Jiang Y,et al.MicroRNA-519c-3p promotes tumor growth and metastasis of hepatocellular carcinoma by targeting BTG3[J].Biomed Pharmacother,2019,118:109267.
22 Han S,Wang L,Sun L,et al.MicroRNA-1251-5p promotes tumor growth and metastasis of hepatocellular carcinoma by targeting AKAP12[J].Biomed Pharmacother,2020,122:109754.
23 Jaitner C,Reddy C,Abentung A,et al.Satb2 determines miRNA expression and long-term memory in the adult central nervous system[J].Elife,2016,5:e17361.
24 Wang Y,Li CF,Sun LB,et al.microRNA-4270-5p inhibits cancer cell proliferation and metastasis in hepatocellular carcinoma by targeting SATB2[J].Hum Cell,2020,33(4):1155-1164.
25 Dou Z,Lu F,Hu J,et al.MicroRNA-6838-5p suppresses the self-renewal and metastasis of human liver cancer stem cells through downregulating CBX4 expression and inactivating ERK signaling[J].Biol Chem,2023,404(1):29-39.
26 Yue X,Cui Y,You Q,et al.MicroRNA-124 negatively regulates chloride intracellular channel 1 to suppress the migration and invasion of liver cancer cells[J].Oncol Rep,2019,42(4):1380-1390.
27 Xu XP,Peng XQ,Yin XM,et al.miR-34a-5p suppresses the invasion and metastasis of liver cancer by targeting the transcription factor YY1 to mediate MYCT1 upregulation[J].Acta Histochem,2020,122(6):151576.
28 Harding V,Stebbing J.Liquorice:a treatment for all sorts?[J].Lancet Oncol,2017,18(9):1155.
29 Abdel-Wahab AA,Effat H,Mahrous EA,et al.A licorice roots extract induces apoptosis and cell cycle arrest and improves metabolism via regulating mirnas in liver cancer cells[J].Nutr Cancer,2021,73(6):1047-1058.
30 He GN,Bao NR,Wang S,et al.Ketamine induces ferroptosis of liver cancer cells by targeting lncRNA PVT1/miR-214-3p/GPX4[J].Drug Des Devel Ther,2021,15:3965-3978.
31 Xu X,Jiang W,Han P,et al.MicroRNA-128-3p mediates lenvatinib resistance of hepatocellular carcinoma cells by downregulating c-Met[J].J Hepatocell Carcinoma,2022,9:113-126.
32 Ragheb MA,Soliman MH,Elzayat EM,et al.MicroRNA-520c-3p modulates doxorubicin-chemosensitivity in HepG2 cells[J].Anticancer Agents Med Chem,2021,21(2):237-245.
33 Fu H,Zhang J,Pan T,et al.miR-378a enhances the sensitivity of liver cancer to sorafenib by targeting VEGFR,PDGFRβ and c-Raf[J].Mol Med Rep,2018,17(3):4581-4588.
34 Fang Y,Yan D,Wang L,et al.Circulating microRNAs(miR-16,miR-22,miR-122)expression and early diagnosis of hepatocellular carcinoma[J].J Clin Lab Anal,2022,36(7):e24541.
35 Zuo D,Chen L,Liu X,et al.Combination of miR-125b and miR-27a enhances sensitivity and specificity of AFP-based diagnosis of hepatocellular carcinoma[J].Tumour Biol,2016,37(5):6539-6549.

[1]	ZHANG Hua, Nurbia Ibibulla, LU Pengfei, JIA Chunli, PEI Xuanxuan, BAO Yongxing. Effect and mechanism of CXCL8 on the paclitaxel sensitivity of cervical cancer cells [J]. Journal of Practical Oncology, 2025, 39(1): 13-20.
[2]	GU Na, TAN Cheng, WANG Luyao, SHEN Hongsheng, LI Xijing, LI Xinyan, LIU Cuicui, ZHAO Xiumei. Effects of maytansine on proliferation,migration,invasion,apoptosis and autophagy of human thyroid cancer cells [J]. Journal of Practical Oncology, 2025, 39(1): 21-29.
[3]	LI Xiaoli, CAO Sujuan, HU Xiaomao, DENG Yujie, TANG Liting, ZHANG Zhongshan. Effects of miRNA-383-5p targeting CIP2A on the proliferation,invasion,migration and apoptosis of bladder cancer cells [J]. Journal of Practical Oncology, 2025, 39(1): 30-38.
[4]	FAN Yunyuan, TANG Xian, WEN Hongmei, SHAO Ying, SHI Jingyin, ZHANG Shuangquan. Analysis of the incidence and mortality of liver cancer in cancer registration areas of Yunnan province in 2020 and the trend from 2012 to 2020 [J]. Journal of Practical Oncology, 2024, 38(6): 377-382.
[5]	YANG Xiaobin, WANG Junping. Effects of BTg-3 on proliferation,invasion,migration and Akt/GSK-3β/β-catenin signaling pathway of liver cancer cells [J]. Journal of Practical Oncology, 2024, 38(6): 410-416.
[6]	LI Qianni, XU Lingyan, LI Jian, YAO Xuepei, LIU Meina. Trend analysis of a longitudinal evaluation for multidimensional treatment quality of breast cancer [J]. Journal of Practical Oncology, 2024, 38(4): 213-220.
[7]	XU Lingyan, LI Qianni, LI Jian, YAO Xuepei, LIU Meina. Analysis for the impact of the first hospitalization days on treatment quality in patients with non-small cell lung cancer [J]. Journal of Practical Oncology, 2024, 38(4): 221-226.
[8]	LI Jian, LI Qianni, XU Lingyan, YAO Xuepei, LIU Meina. Research on the causal effects of non-small cell lung cancer treatment process on in-hospital mortality based on double robust estimation method [J]. Journal of Practical Oncology, 2024, 38(4): 235-240.
[9]	CHENG Yongming, DONG Huanhuan, XU Hui. Hsa-let-7b-5p inhibits proliferation,migration and invasion in non-small cell lung cancer [J]. Journal of Practical Oncology, 2024, 38(3): 157-167.
[10]	TANG Dong, GAO Wenhong, ZHANG Huaping, CHEN Qianxue. Effects of morusin on the migration and invasion of U87 cells [J]. Journal of Practical Oncology, 2024, 38(3): 168-172.
[11]	HOU Mingxing, WEI Yonggang. A Meta-analysis of the clinical efficacy of hepatic arterial chemoembolization combined with second-stage surgical resection and hepatic arterial chemoembolization alone for unresectable intermediate and advanced liver cancer in Chinese population [J]. Journal of Practical Oncology, 2024, 38(2): 112-120.
[12]	XU Qianshu, XIA Tianyi. Research progress on tumor related depression [J]. Journal of Practical Oncology, 2024, 38(2): 131-135.
[13]	BO Yun, HANG Wenlu, ZUO Shurun, Dong Yuan, LI Haiquan. Effects of long non-coding RNA OTUD6B-AS1 on proliferation,invasion and migration of lung adenocarcinoma A549 cells [J]. Journal of Practical Oncology, 2024, 38(1): 13-17.
[14]	DENG Jielian, ZHENG Wei, LI Kangjie, ZHANG Cong, ZHANG Yuan, XIE Biao, ZHONG Xiaoni. Construction of a prognostic risk prediction model in liver cancer for macrophage related genes based on single-cell RNA-seq and bulk RNA-seq data [J]. Journal of Practical Oncology, 2023, 37(5): 403-410.
[15]	PANG Wu, CHEN Lijiang, ZHU Yu, WU Yakun, ZHANG Wei. The expression of serum miRNA-24 and miRNA-509 in patients with hepatocellular carcinoma and their correlation with prognosis [J]. Journal of Practical Oncology, 2023, 37(5): 411-415.

Expression and mechanism of miRNA in the occurrence and development of hepatocellular carcinoma

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments