实用肿瘤学杂志 ›› 2014, Vol. 28 ›› Issue (4): 349-353.doi: 10.11904/j.issn.1002-3070.2014.04.013

• 综述 • 上一篇    下一篇

诺尼抗肿瘤作用及其机制的研究进展

陈建国1 李金霞1, 2,3 综述 程池?审校   

  1. 1中国食品发酵工业研究院(北京,100015);2中国工业微生物菌种保藏管理中心;3天津科技大学生物工程学院
  • 出版日期:2014-08-28 发布日期:2014-07-31
  • 作者简介:陈建国,男,(1980-),博士,工程师,从事保健原材的功效物质及其作用机制研究

Progress on antitumor activity and its mechanisms of morinda citrifolia

CHEN Jianguo1, LI Jinxia1,2,3, CHENG Chi1   

  1. 11.China National Research Institute of Food and Fermentation Industries,Beijing 100015,China ;2China Center of Industrial Culture Collection;3Tianjin University of Science & Technology, College of Bioengineering
  • Online:2014-08-28 Published:2014-07-31

摘要: 摘要本文概述了近十多年来国内外有关诺尼抗肿瘤作用及其机制的研究进展,大量试验表明诺尼果汁、果汁提取物、叶子和根提取物均有抗肿瘤作用,可通过诱导肿瘤细胞凋亡、激活宿主免疫系统、抑制血管生成、抗氧化、抑制环氧化酶和阻止致癌物-DNA加合物形成等机制来抑制肿瘤生长。本文希望能为研发以诺尼为原料辅助治疗癌症的药物和食品提供参考。

关键词: 诺尼, 海巴戟天, 抗肿瘤, 机制

Abstract: AbstractThis paper summarizes the progress on anti-tumor effect and its mechanism of Noni over the past decade. Plenty of tests indicated that noni juice, juice extracts, leaf and root extracts have anti-tumor effects. It can inhibit tumor growth through inducing tumor cell apoptosis, activating host immune system, inhibition of angiogenesis and cyclooxygenase, anti-oxidation and blocking carcinogen -DNA adduct formation. This paper provides a reference for the adjuvant therapy of anticancer drugs and food form Noni.

Key words: noni, Morinda citrifolia Linn, Anticancer, Mechanism

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