HIF-1与肿瘤相关性研究进展

doi:10.11904/j.issn.1002-3070.2014.06.018

摘要/Abstract

摘要：

转录因子-缺氧诱导因子-1(HIF-1)在细胞适应从常氧(21%O₂)到低氧(1%O₂)的过程中扮演了重要角色。研究表明,HIF-1与人类多种恶性肿瘤的发生发展有着密切关系。本文就HIF-1在肿瘤的增殖、转移、凋亡和血管生成中的作用进行综述。

关键词: 缺氧, 缺氧诱导因子-1, 肿瘤

Abstract:

Transcription factorhypoxia inducible factor-1(HIF-1)plays a key role in cell adaption to hypoxia(from 21% O₂ to 1% O₂).Researches have shown that HIF-1 is closely related to occurrence and development in many malignant cancers.In this paper,we review the effect of HIF-1 in tumor growth,metastasis,apoptosis and angiogenesis.

Key words: Hypoxia, HIF-1, Neoplasms

中图分类号:

R730.1

张博综述, 赵刚审校. HIF-1与肿瘤相关性研究进展[J]. 实用肿瘤学杂志, 2014, 28(6): 565-568.

ZHANG Bo,ZHAO Gang. Research progress of HIF-1 in cancers[J]. PRACTICAL ONCOLOGY JOURNAL, 2014, 28(6): 565-568.

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