TLR3对NF-κB信号通路的调控在肿瘤中的意义

doi:10.11904/j.issn.1002-3070.2015.06.013

摘要/Abstract

摘要： 核因子κB(Nuclear factor-kappa B,NF-κB)是转录因子Rel蛋白家族成员,在所有细胞中都有表达,参与细胞重要的生理、病理过程,具有复杂的调控机制,而TLR3对NF-κB信号通路的调控作为当前研究的热点,受到广泛的关注。本文对此进行综述,重点阐明其调控的分子机制,总结调控中相关信号分子所介导的宿主免疫反应在肿瘤发生发展中的作用,揭示该调控中的一些关键蛋白作为治疗靶点对于疾病治疗的重大意义,从而对肿瘤组织功能性和多样性有更多的理解。

关键词: TLR3, NF-κB, TRIF, 信号转导, 肿瘤

Abstract: NF-κBs is a member of Rel protein family of transcription factors,which is expressed in all cells and is involved in important physiological and pathological regulatory mechanisms,including the regulation of TLR3 on NF-κB signaling pathway,which has been attracted widespread attention.This paper reviews the molecular mechanisms of the regulation.We summarizes the role of host immune responses in tumor development,which is mediated by the related signal molecules.It reveals that some key proteins in the regulation have a great significance to the treatment of diseases,as used as the therapeutic targets,and is conducive to the understanding of function and diversity in tumor tissue.

Key words: TLR3, NF-κB, TRIF, Signal transduction, Tumor

中图分类号:

R392.3

周虹, 陈莉. TLR3对NF-κB信号通路的调控在肿瘤中的意义[J]. 实用肿瘤学杂志, 2015, 29(6): 540-544.

ZHOU Hong, CHEN Li. The regulation of TLR3 on NF-κB signaling pathway and its significance in the pathogenesis of tumor[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(6): 540-544.

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