长链非编码RNA与肿瘤耐药性的研究进展

doi:10.11904/j.issn.1002-3070.2016.02.012

实用肿瘤学杂志 ›› 2016, Vol. 30 ›› Issue (2): 150-153.doi: 10.11904/j.issn.1002-3070.2016.02.012

长链非编码RNA与肿瘤耐药性的研究进展

池淑琦综述, 汪宏波审校

华中科技大学同济医学院附属协和医院妇产科(武汉 430022)

收稿日期:2015-06-02 出版日期:2016-04-28 发布日期:2016-04-28
通讯作者: 汪宏波,E-mail:whbdf@yahoo.com
作者简介:池淑琦,女,(1992-),硕士研究生,从事妇科肿瘤相关的研究

LncRNAs and drug resistance in tumors

CHI Shuqi, WANG Hongbo

Department of Obstetrics and Gynecology,Union Hospital,Huazhong University of Science and Technology & Tongji Medical College,Wuhan 430022,China.

Received:2015-06-02 Online:2016-04-28 Published:2016-04-28

摘要/Abstract

摘要： 化学药物治疗(简称化疗)是癌症患者的主要治疗方法之一,但肿瘤的多药耐药(Multidrug resistance,MDR)是限制目前肿瘤化疗方案疗效的基本问题,其耐药机制至今尚未被完全阐明。lncRNAs可通过表观修饰、转录、转录后加工等多种途径调节基因表达。近期研究表明,lncRNAs对靶基因的异常调控与肿瘤耐药密切相关。因此,lncRNAs有望成为提高肿瘤的化疗敏感性,逆转化疗耐药的新靶点。本文就近年来lncRNAs与肿瘤耐药关系及调控机制的研究进展做一综述。

关键词: 长链非编码RNA, 肿瘤耐药性, 基因表达调控

Abstract: Chemotherapy is one of the primary treatments for cancer patients,while tumor multidrug resistance(MDR)represents a major obstacle in the treatments of patients,limiting the efficacy of chemotherapy.To date,the mechanism of drug resistance has not been fully elucidated.lncRNAs are a family of long noncoding RNAs that regulate gene expression by epigenetic modification,transcription and post transcriptional processing.Recent studies have showed that the aberrant regulation of target genes by lncRNAs may be involved in the acquisition of tumor MDR.Therefore,targeting lncRNAs may be an attractive strategy for improving the chemosentivity and reversing chemotherapeutic resistance.This paper reviews the relationship between lncRNAs and tumor drug resistance as well as the underlying possible mechanism.

Key words: LncRNAs, Tumor multidrug resistance, Gene expression regulation

中图分类号:

池淑琦综述, 汪宏波审校. 长链非编码RNA与肿瘤耐药性的研究进展[J]. 实用肿瘤学杂志, 2016, 30(2): 150-153.

CHI Shuqi, WANG Hongbo. LncRNAs and drug resistance in tumors[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(2): 150-153.

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长链非编码RNA与肿瘤耐药性的研究进展

LncRNAs and drug resistance in tumors

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