FAK在恶性肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2016.02.015

摘要/Abstract

摘要： 黏着斑激酶(Focal adhesion kinase,FAK)是细胞内重要的骨架蛋白,属于一种非受体型酪氨酸蛋白激酶,也是多种信号通路的关键性分子。在肿瘤发生、发展、迁移以及侵袭的各个阶段FAK都具有重要作用。近年来,人们对FAK的研究越来越多,综合国内外研究资料表明,FAK在许多肿瘤组织中表达增高,提示FAK可能与肿瘤的发生发展密切相关,可能是肿瘤治疗的潜在靶点。该综述将对FAK分子结构及功能特点,与肿瘤的关系进行系统阐述。

关键词: 黏着斑激酶, 肿瘤, 信号通路

Abstract: Focal adhesion kinase(FAK),a cytoplasmic non-receptor protein tyrosine kinase,serves as both a molecular scaffold and a mediator participating in multiple signal transduction pathways.FAK is involved in tumor cell survival,proliferation,migration and metastasis.Recent studies have shown that FAK is expressed in many tumor cells.Currently,FAK has been regarded as a potential target for cancer therapy.This review is to summarize the relationship between FAK and tumor progression.

Key words: Focal adhesion kinase, Cancer, Signal pathway

中图分类号:

赵美娜综述, 陈公琰审校. FAK在恶性肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2016, 30(2): 162-166.

ZHAO Meina, CHEN Gongyan. Research progress on focal adhesion kinase in malignant tumors[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(2): 162-166.

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