ELAM-1在肿瘤靶向治疗中的应用进展

doi:10.11904/j.issn.1002-3070.2016.05.012

摘要/Abstract

摘要： E选择素(Endothelial leukocyte adhesion molecule-1,ELAM-1)是细胞黏附分子家族中的一类,研究表明,ELAM-1与其配体sLe(x)和sLe(a)的相互作用,在肿瘤远处转移的过程中扮演着重要的角色。近年来,将ELAM-1运用于肿瘤靶向治疗的研究,逐渐成为一个新的热点。众多研究成果表明,通过对ELAM-1生物学作用的调控,如ELAM-1及其配体抑制剂、单克隆抗体、靶向基因,以及其他介导等路径阻断疗法等,从而抑制或阻断肿瘤的远处转移,达到治疗肿瘤、改善预后的目的。因此,ELAM-1有望在肿瘤靶向治疗方面发挥重要作用。本文就ELAM-1在肿瘤相关靶向治疗中的应用价值做一综述。

关键词: ELAM-1, 肿瘤, 靶向治疗

Abstract: Endothelial leukocyte adhesion molecule-1(ELAM-1)is a member of the cell adhesion molecules,which plays a great role in the distant metastasis of tumor in ligand interactions between sLe(x)and sLe(a).Recently,it becomes a new research hotspot on applying ELAM-1 in targeted cancer therapy.Many studies Results show that by regulation of ELAM-1 in biological effects,such as ELAM-1 and ligand inhibitors,monoclonal antibody,targeting gene,and other mediates of the path of blocking therapy,thereby inhibiting or blocking tumor distant metastasis,so as to achieve the purpose of tumor therapy and improve the prognosis.Therefore,ELAM-1 is expected to exert a critical role in the tumor targeted therapy.In this paper,the application value of ELAM-1 in tumor related targeted therapy is reviewed.

Key words: ELAM-1, Tumor, Targeted therapy

中图分类号:

R730

左志超, 苏丹柯, 邓文娟综述, 金观桥审校. ELAM-1在肿瘤靶向治疗中的应用进展[J]. 实用肿瘤学杂志, 2016, 30(5): 444-447.

ZUO Zhichao, SU Danke, DENG Wenjuan, JIN Guanqiao. Recent advances of ELAM-1 in targeted cancer therapy[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(5): 444-447.

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