XBP-1在肿瘤发生发展中的研究进展

doi:10.11904/j.issn.1002-3070.2017.01.014

实用肿瘤学杂志 ›› 2017, Vol. 31 ›› Issue (1): 65-68.doi: 10.11904/j.issn.1002-3070.2017.01.014

XBP-1在肿瘤发生发展中的研究进展

倪守华, 岳晓龙综述, 吴瑾审校

哈尔滨医科大学附属肿瘤医院肿瘤内科(哈尔滨 150081)

收稿日期:2016-10-12 出版日期:2017-02-28 发布日期:2017-02-20
通讯作者: 吴瑾,E-mail:w.u_jin@163.com
作者简介:倪守华,男,(1989-),硕士研究生,从事肿瘤内科的研究

The transcription factor X-box binding protein-1 in tumorigenesis and development of cancer

NI Shouhua, YUE Xiaolong, WU Jin

Department of Oncology,The Affiliated Tumor Hospital of Medical University,Harbin 150081,China

Received:2016-10-12 Online:2017-02-28 Published:2017-02-20

摘要/Abstract

摘要： X-盒结合蛋白1(X-box binding protein 1,XBP-l)是一种新近发现的与蛋白质折叠和内质网构建相关的蛋白质,研究发现其在多种肿瘤细胞中均有广泛表达,与肿瘤发生、发展的关系密切。本文对XBP-1参与肿瘤发生、发展过程的免疫逃避、血管生成、缺氧、侵袭转移等方面的研究进展做一综述。

关键词: XBP-1, 免疫逃逸, 血管生成, 肿瘤

Abstract: X-box binding protein-1(XBP-1)is a newly found protein that plays significant roles in protein folding and endoplasmic reticulum construction.The expression of XBP-1 is widely displayed in various kinds of tumor and is shown to take part in tumorigenesis and tumor progression.This review briefly summarizes the biology of XBP-1 and focuses on recent findings concerning its role in immune evasion,tumorigenesis,development of cancer,angiogenesis,hypoxia,invasion and metastasis.

Key words: XBP-1, Immune escape, Angiogenesis, Cancer

中图分类号:

倪守华, 岳晓龙综述, 吴瑾审校. XBP-1在肿瘤发生发展中的研究进展[J]. 实用肿瘤学杂志, 2017, 31(1): 65-68.

NI Shouhua, YUE Xiaolong, WU Jin. The transcription factor X-box binding protein-1 in tumorigenesis and development of cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(1): 65-68.

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XBP-1在肿瘤发生发展中的研究进展

The transcription factor X-box binding protein-1 in tumorigenesis and development of cancer

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