关键词: 氟比洛芬酯, 舒芬太尼, 宫颈癌, 免疫因子

Abstract: Objective The objective of this study was to investigate the analgesic effect of flurbiprofen axetil and its effect on immune factors after cervical cancer surgery. Methods Ninety patients with cervical cancer undergoing laparoscopic surgery were randomly divided into three groups with 30 patients in each group in Zhongshan Hospital Affiliated to Dalian University from January 2016 to June 2017.The indexes of assessment were visual assessment of visual analog scale(VAS)pain assessment and postoperative adverse reaction at 2,12,24 and 48 h after operation.The levels of CD4,CD8,IL-1,IL-6,CD4/CD8 and PGEs in the serum at 12,24 and 48 h after operation were measured. Results The VAS scores in the A group were significantly lower than those in the B and C groups during 12 and 24 h after operation(P＜0.05).But there were no significant differences in the levels of CD4,CD8,IL-1,IL-6,CD4/CD8 and PGEs amongst the three groups(P＞0.05).The levels of IL-1 and IL-6 at 2,12 and 24 h after operation were significantly higher than those in the baseline(P＜0.05).However,the levels of IL-1 and IL-6 in the C group was significantly higher than those in the A and B groups(P＜0.05).Compared to before operation,the ratio of CD4/CD8 was decreased and the level of PGE2 was increased in the three groups after operation.After 24 h operation,the ratio of CD4/CD8 in the B group were significantly lower than that in the C group(P＜0.05).The level of PGE2 at 12 h after operation was significantly increased in the B and C groups(P＜0.05). Conclusion The combination of flurbiprofen axetil and sufentanil in the laparoscopic surgery of cervical cancer can improve postoperative analgesia and reduce adverse reactions,effectively reduce the secretion of inflammatory mediators and minor affect on cellular immune function.

Key words: Flurbiprofen axetil, Sufentanil, Cervical cancer, Immune factors