QKI蛋白在恶性肿瘤中的研究进展及临床意义

doi:10.11904/j.issn.1002-3070.2018.03.015

实用肿瘤学杂志 ›› 2018, Vol. 32 ›› Issue (3): 263-266.doi: 10.11904/j.issn.1002-3070.2018.03.015

QKI蛋白在恶性肿瘤中的研究进展及临床意义

张婷¹, 侯光营², 王鑫³(综述), 贺岩¹(审校)

1.哈尔滨医科大学病理教研室(哈尔滨 150081);
2.河北省沧州市中西医结合医院肿瘤内科;
3.哈尔滨医科大学附属第二医院耳鼻喉头颈外科

收稿日期:2017-06-22 出版日期:2018-07-10 发布日期:2018-07-10
通讯作者: 贺岩,E-mail:he_yan419@163.com
作者简介:张婷,女,(1989-),硕士研究生,从事恶性肿瘤发病机制的研究
基金资助:
国家自然科学基金青年基金(编号:81400443)

Research progress and clinical significance of QKI protein in malignant tumor

ZHANG Ting,HOU Guangying,WANG Xin,HE Yan

1.Department of Pathology,Harbin Medical University,Harbin 150081,China;
2.Department of Oncology,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine;
3.Department of Otorhinolaryngology and Neck Surgery,The Second Affiliated Hospital of Harbin Medical University

Received:2017-06-22 Online:2018-07-10 Published:2018-07-10

摘要/Abstract

摘要： QKI蛋白是STAR蛋白家族的一员,主要包含QKI-5、QKI-6和QKI-7三个亚型,早期研究发现QKI蛋白与神经髓鞘和胚胎发育密切相关。随着分子生物学的发展和基因技术的广泛应用,QKI蛋白在恶性肿瘤中的作用日益受到人们的重视。QKI蛋白在肺癌、胃癌、前列腺癌中的研究显示了其有抑制肿瘤侵袭能力的作用,并有可能成为一种恶性肿瘤诊断和治疗的新靶点。尽管QKI蛋白在恶性肿瘤中的广泛研究取得了重大进展,然而还存在许多疑点需要解答,有待于进一步的研究。

关键词: QKI蛋白, 恶性肿瘤, 抑制肿瘤

Abstract: QKI protein is a kind of STAR protein family and mainly contains three subtypes of QKI-5,QKI-6 and QKI-7.Early studies showed that QKI protein is closely related to the development of nerve myelin and embryo.With the development of molecular biology and the extensive application of gene technology,the effect of QKI protein on malignant tumors has received increasing attention.The studies of QKI protein from lung,gastric and prostate cancers have shown that it has the ability to inhibit tumor invasion,and may become a new target for the diagnosis and treatment of malignant tumors.Although significant progress has been made in the extensive research of QKI protein in malignant tumors,there are still many doubtful points that need to be answered.Thus,further research and exploration of QKI are needed in malignant tumor.

Key words: QKI protein, Malignant tumor, Tumor suppression

中图分类号:

R730.43

张婷, 侯光营, 王鑫(综述), 贺岩(审校). QKI蛋白在恶性肿瘤中的研究进展及临床意义[J]. 实用肿瘤学杂志, 2018, 32(3): 263-266.

ZHANG Ting, HOU Guangying, WANG Xin, HE Yan. Research progress and clinical significance of QKI protein in malignant tumor[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 263-266.

参考文献

1 Suiko T,Kobayashi K,Aono K,et al.Expression of quaking RNA-binding protein in the adult and developing mouse retina[J].PLoS One,2016,11(5):e0156033.
2 Artzt K,Wu JI.STAR trek:An introduction to STAR family proteins and review of quaking(QKI)[J].Adv Exp Med Biol,2010,693:1-24.
3 Teplova M,Hafner M,Teplov D,et al.Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites[J].Gene Dev,2013,27(8):928-940.
4 Darbelli L,Richard S.Emerging functions of the quaking RNA-binding proteins and link to human diseases[J].Wiley Interdiscip Rev RNA,2016,7(3):399-412.
5 Bryn F,Christiane P,Bettina Z,et al.Gene expression of quaking in sporadic Alzheimer′s disease patients is both upregulated and related to expression levels of genes involved in amyloid plaque and neurofibrillary tangle formation[J].J Alzheimers Dis,2016,53(1):209-219.
6 Shu P,Fu H,Zhao X,et al.MicroRNA-214 modulates neural progenitor cell differentiation by targeting quaking during cerebral cortex development[J].Scientific Reports,2017,7(1):8014.
7 Pachecopinedo EC,Durham AC,Stewart KM,et al.Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium[J].J Clin Invest,2011,121(5):1935-1945.
8 Ji S1,Ye G,Zhang J,et al.MiR-574-5p negatively regulates QKI6/7 to impact β-catenin/Wnt signalling and the development of colorectal cancer[J].Gut,2013,62(5):716-726.
9 De Miguel FJ,Pajares MJ,Martínez-Terroba E,et al.A large‐scale analysis of alternative splicing reveals a key role of QKI in lung cancer[J].Mol Oncol,2016,10(9):1437-1449.
10 Zhao L,Tian D,Xia M,et al.Rescuing qkV dysmyelination by a single isoform of the selective RNA-binding protein QKI[J].J Neurosci,2006,26(44):11278-11286.
11 Kantarjian HM,Thomas XG,Dmoszynska A,et al.Multicenter,randomized,open-label,phase Ⅲ trial of decitabine versus patient choice,with physician advice,of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloidleukemia[J].Clin Oncol,2012,30(21):2670-2677.
12 Garciamanero G,Jabbour E,Borthakur G,et al.Randomized open-label phase Ⅱ study of decitabine in patients with low- or intermediate-risk myelodysplastic syndromes[J].J Clin Oncol,2013,31(20):2548-2553.
13 侯光营,王艳.血清KL-6黏蛋白及Clara细胞分泌蛋白检测在非小细胞肺癌的应用价值及其研究进展[J].中国综合临床,2016,32(12):1149-1152.
14 Liu Z,Wang X,Lu Y,et al.Expression of 15-PGDH is downregulated by COX-2 in gastric cancer[J].Carcinogenesis,2008,29(6):1219-1227.
15 Salcedo R,Zhang X,Young HA,et al.Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells[J].Blood,2003,102(6):1966-1977.
16 王黎.RNA结合蛋白QKI通过转录后调节COX2抑制胃癌的发生发展[D].西安:第四军医大学,2012.
17 Bian Y,Wang L,Lu H,et al.Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosis[J].Biochem Bioph Res Co,2012,422(1):187-193.
18 Iwata N,Ishikawa T,Okazaki S,et al.Clinical significance of methylation and reduced expression of the quaking gene in colorectal cancer[J].Anticancer Res,2017,37(2):489-498.
19 崔明凯,张伟,刘波,等.RNA 结合蛋白 QKI-5在直肠癌组织中异常表达的研究[J].河北医药,2016,38(2):181-184.
20 Yu F,Jin L,Yang G,et al.Post-transcriptional repression of FOXO1 by QKI results in low levels of FOXO1 expression in breast cancer cells[J].Oncology Reports,2014,31(3):1459-1465.
21 Zhang RL,Yang JP,Peng LX,et al.RNA-binding protein QKI-5 inhibits the proliferation of clear cell renal cell carcinoma via post-transcriptional stabilization of RASA1 mRNA[J].Cell Cycle,2016,15(22):3094-3104.
22 Zhao Y,Zhang G,Wei M,et al.The tumor suppressing effects of QKI-5 in prostate cancer:A novel diagnostic and prognostic protein[J].Cancer Biol Ther,2014,15(1):108-118.
23 He Z,Yi J,Liu X,et al.MiR-143-3p functions as a tumor suppressor by regulating cell proliferation,invasion and epitheliala-mesenchymal transition by targeting QKI-5 in esophageal squamous cell carcinoma[J].Molecular Cancer,2016,15(1):51.
24 Fu X,Feng Y.QKI-5 suppresses cyclin D1 expression and proliferation of oral squamous cell carcinoma cells via MAPK signalling pathway.[J].Int J Oral Maxillofac Surg,2015,44(5):562.
25 Zheng ZL,Kondo T,Murata T,et al.Expression of Hqk encoding a KH RNA binding protein is altered in human glioma[J].Cancer Science,2002,93(2):167-177.
26 Lu W,Feng F,Xu J,et al.QKI impairs self-renewal and tumorigenicity of oral cancer cells via repression of SOX2[J].Cancer Biol Ther,2014,15(9):1174-1184.
27 Esmerina T,Marcela C,Dario P,et al.Quaking and miR-155 interactions in inflammation and leukemogenesis[J].Oncotarget,2015,6(28):24599.
28 Mazanmamczarz K,Kuwano Y,Zhan M,et al.Identification of a signature motif in target mRNAs of RNA-binding protein AUF1[J].Nucleic Acids Res,2009,37(1):204-214.

[1]	张茂祥,孙惠昕,宋冰冰. 2008—2012年哈尔滨市道里区恶性肿瘤发病与死亡分析[J]. 实用肿瘤学杂志, 2019, 33(3): 261-265.
[2]	李诚, 兰莉, 杨超, 张婷婷, 王蕊, 林琳, 田文静. 2015—2017年哈尔滨市恶性肿瘤发病与死亡特征分析[J]. 实用肿瘤学杂志, 2019, 33(1): 62-66.
[3]	韩滕综述, 唐丽萍审校. PD-L1的表达与妇科恶性肿瘤预后关系的研究进展[J]. 实用肿瘤学杂志, 2018, 32(5): 468-470.
[4]	韩帮岭, 汪亦民, 薛英威. 中性粒细胞与恶性肿瘤关系的研究进展[J]. 实用肿瘤学杂志, 2018, 32(4): 349-352.
[5]	周洁, 陈钰(综述), 陈道桢(审校). 纳米材料在肿瘤光动力治疗中的应用[J]. 实用肿瘤学杂志, 2018, 32(3): 245-249.
[6]	侯思宇(综述), 陈秀玮(审校). JMJD2B蛋白结构功能及在恶性肿瘤发生发展中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(3): 250-253.
[7]	纪巧, 陈丽(综述), 何远桥(审校). 三维组织药敏法在肿瘤个体化精准医疗中的应用[J]. 实用肿瘤学杂志, 2018, 32(3): 280-284.
[8]	李静,张云艳. miR-331-3p在恶性肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(2): 125-129.
[9]	张永欣, 黄河. Galectin-9与多种恶性肿瘤的研究进展及作用机制探讨[J]. 实用肿瘤学杂志, 2018, 32(2): 159-163.
[10]	吴逸飞, 刘宝刚. 硫氧还蛋白还原酶2在恶性肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(2): 174-178.
[11]	韩雪娇, 李艳春, 孙立春, 鲁海玲审校. 14-3-3ζ与恶性肿瘤关系的研究进展[J]. 实用肿瘤学杂志, 2017, 31(6): 543-547.
[12]	江莹, 刘宝刚审校. RCAN1在恶性肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2017, 31(6): 559-563.
[13]	孙禹琪,陈秀玮. CTGF/CCN2在恶性肿瘤的发生发展及靶向治疗中的研究进展[J]. 实用肿瘤学杂志, 2017, 31(4): 363-366.
[14]	霍明娟,孟祥程,孙影,程丽. ALCAM在妇科恶性肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2017, 31(4): 381-384.
[15]	郝立肖(综述), 张云艳(审校). AIM2在肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2017, 31(2): 175-178.

QKI蛋白在恶性肿瘤中的研究进展及临床意义

Research progress and clinical significance of QKI protein in malignant tumor

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价