锰超氧化物歧化酶在肿瘤发生发展过程中的研究进展

doi:10.11904/j.issn.1002-3070.2018.06.016

摘要/Abstract

摘要： 活性氧与肿瘤的发生发展有着密切关系。锰超氧化物歧化酶(MnSOD)作为清除线粒体基质中超氧阴离子的抗氧化酶, 对维持线粒体的氧化还原稳态、保护线粒体DNA具有极为重要的作用。研究发现MnSOD在不同肿瘤中的表达水平不一, 同时具有抑癌和促癌双面功能, 但其功能转换机制仍不明晰。本文拟探讨MnSOD在肿瘤发生发展中的作用, 并对其表达水平和活性的主要调控机制进行综述。

关键词: 锰超氧化物歧化酶, 活性氧, 肿瘤

Abstract: Reactive oxygen is closely related to the occurrence and development of tumors.Manganese superoxide dismutase(MnSOD), as an antioxidant enzyme that scavenges superoxide anion in the mitochondrial matrix, plays an important role in maintaining mitochondrial redox homeostasis and protecting mitochondrial DNA.Many studies have discovered that MnSOD has different expression levels in different tumors, and has both anti-cancer and cancer-promoting functions, but its functional conversion mechanism remains unclear.This article intends to investigate the role of MnSOD in tumorigenesis and development, and to review the main regulatory mechanisms of its expression level and activity.

Key words: Manganese superoxide dismutase, Reactive oxygen species, Neoplasms

中图分类号:

顾琦晟综述, 李继坤审校. 锰超氧化物歧化酶在肿瘤发生发展过程中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(6): 562-566.

GU Qisheng, LI Jikun. Progress in manganese superoxide dismutase in tumor development[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 562-566.

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