长链非编码RNA在骨肉瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2019.03.014

摘要/Abstract

摘要： 骨肉瘤(Osteosarcoma,OS)是一种多发于儿童及青少年的骨恶性肿瘤,预后极差,患者5年生存率及出现肺转移或远处转移的患者生存率仍不理想,目前骨肉瘤的治疗基本处于瓶颈期。长链非编码RNA(Long non-coding RNA,LncRNA)是构成非蛋白质编码的RNA分子,它们涉及多种过程,包括基因表达、染色质重塑、转录后加工和转录。长链非编码RNA在人类癌症中异常表达,并且它们参与肿瘤发展、进展和转移。本文就长链非编码RNA在骨肉瘤中的研究进展进行综述,意在为骨肉瘤的进一步研究及提出新的诊疗策略提供帮助。

关键词: 骨肉瘤, 长链非编码RNA, 肿瘤

Abstract: Osteosarcoma(OS)is a malignant tumor that occurs mostly in children and adolescents with a poor prognosis.The 5-year survival rate and the survival rate of patients with lung metastasis or distant metastasis are still unsatisfactory.Currently,the treatment of osteosarcoma is still unsatisfactory under the bottleneck period.Long-chain non-coding RNA(LncRNA)is a non-protein-encoding RNA molecule involved in a variety of processes including gene expression,chromatin remodeling,post-transcriptional processing and transcription.LncRNAs are abnormally expressed in human cancers and they are involved in tumor development,progression and metastasis.This article reviews the research progress of long-chain non-coding RNA in osteosarcoma,which is intended to provide further research for osteosarcoma and propose new diagnosis and treatment strategies.

Key words: Osteosarcoma, Long-chain non-coding RNA, Tumor

中图分类号:

R738.1

刘乙澍,曲国蕃. 长链非编码RNA在骨肉瘤中的研究进展[J]. 实用肿瘤学杂志, 2019, 33(3): 266-270.

LIU Yishu,QU Guofan. Progress in long-chain non-coding RNA in osteosarcoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 266-270.

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