大蒜素抑制消化道肿瘤细胞增殖作用的研究进展

doi:10.11904/j.issn.1002-3070.2020.03.012

实用肿瘤学杂志 ›› 2020, Vol. 34 ›› Issue (3): 254-257.doi: 10.11904/j.issn.1002-3070.2020.03.012

大蒜素抑制消化道肿瘤细胞增殖作用的研究进展

王浩冉¹(综述), 张玲²(审校)

1.内蒙古科技大学包头医学院中心临床医学院(包头 014040);
2.内蒙古自治区包头市中心医院消化内科

收稿日期:2019-11-13 修回日期:2019-12-30 发布日期:2020-06-30
通讯作者: 张玲,E-mail:nmgbtzl2013@163.com
作者简介:王浩冉,女,(1991-),硕士研究生,从事消化系统肿瘤防治的研究
基金资助:
1.内蒙古自然科学基金项目(编号:2016MS0894);2.内蒙古医科大学科技百万工程联合项目(编号:YKD2018KJBW(LH)083)

Research progress of diallyltrisulfide in inhibiting proliferation of digestive tract tumor cells

WANG Haoran¹,ZHANG Ling²

1.Department of Gastroenterology,Clinical College of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014040,China;
2.Department of Gastroenterology,Baotou Central Hospital,Inner Mongolia Autonomous Region

Received:2019-11-13 Revised:2019-12-30 Published:2020-06-30

摘要/Abstract

摘要： 大蒜素是大蒜中一种含硫化合物的特有成分,是多种含硫化合物的复合体,研究证实大蒜素对多种肿瘤细胞的增殖具有抑制作用。近年来,大蒜素对消化道肿瘤细胞增殖抑制作用的相关研究备受关注。大量研究表明大蒜素可抑制食管癌、胃癌、肝癌、胰腺癌、结肠癌细胞的生长,其作用机制与影响细胞信号转导、抑制细胞生长和诱导细胞凋亡有关。大蒜素抑制消化道肿瘤细胞增殖的机制是一个较复杂的细胞生物学过程,目前具体机制尚未完全明确,因此本文对大蒜素抑制消化道肿瘤细胞增殖作用机制的相关研究进展进行简要综述。

关键词: 大蒜素, 消化道肿瘤, 抑制作用

Abstract: Diallyltrisulfide is a unique component of a sulfur-containing compound in garlic,and it is a complex of multiple sulfur-containing compounds.Studies have shown that diallyltrisulfide can inhibit the proliferation of a variety of tumor cells.In recent years,many studies have attracted much attention on the inhibitory effect of diallyltrisulfide on proliferation of digestive tract tumor cells.A large number of studies have shown that diallyltrisulfide can inhibit the growth of esophageal cancer,gastric cancer,liver cancer,pancreatic cancer and colon cancer cells,and its mechanism of action is related to affecting cell signal transduction,inhibiting cell growth and inducing apoptosis.The mechanism of diallyltrisulfide inhibiting the proliferation of gastrointestinal tumor cells is a more complicated cell biological process,and the specific mechanism has not yet been fully clarified at present.Therefore,this paper briefly reviews the relevant research progress of the mechanism of diallyltrisulfide inhibiting proliferation of gastrointestinal tumor cells.

Key words: Diallyltrisulfide, Digestive tract tumor, Inhibitory effect

中图分类号:

R735

王浩冉, 张玲. 大蒜素抑制消化道肿瘤细胞增殖作用的研究进展[J]. 实用肿瘤学杂志, 2020, 34(3): 254-257.

WANG Haoran,ZHANG Ling. Research progress of diallyltrisulfide in inhibiting proliferation of digestive tract tumor cells[J]. Journal of Practical Oncology, 2020, 34(3): 254-257.

0
/ / 推荐

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2020.03.012

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2020/V34/I3/254

参考文献

1 陶庆霞,张鹏,吴翠莹,等.大蒜素抗肿瘤作用及其机制的研究进展[J].中华神经创伤外科电子杂志,2016,2(6):365-368.
2 Borlinghaus J,Albrecht F,Gruhlke MC,et al.Allicin:chemistry and biological properties[J].Molecules,2014,19(8):12591-12618.
3 Zhang W,Ha M,Gong Y,et al.Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways[J].Oncol Rep,2010,24(6):1585-1592.
4 Hirsch K,Danilenko M,Giat J,et al.Effect of purified allicin,the major ingredient of freshly crushed garlic,on cancer cell proliferation[J].Nutr Cancer,2000,38(2):245-254.
5 Reichenbach ZW,Murray MG,Saxena R,et al.Clinical and translational advances in esophageal squamous cell carcinoma[J].Adv Cancer Res,2019,144:95-135.
6 Riaz SK,Iqbal Y,Malik MF.Diagnostic and therapeutic implications of the vascular endothelial growth factor family in cancer[J].Asian Pac J Cancer Prev,2015,16(5):1677-1682.
7 Karaman S,Leppnen VM,Alitalo K.Vascular endothelial growth factor signaling in development and disease[J].Development,2018,145(14):151019.
8 陈宇,袁丽.大蒜素抑制Wnt/β-catenin通路对晚期食管癌中VEGF的调控作用[J].解剖学研究,2018,40(6):485-488.
9 曹成章,胡树桥,赖海银,等.大蒜素与化疗药物对食管癌细胞EC109疗效比较的实验研究[J].中国病理生理杂志,2017,33(10):1845-1851.
10 张召,梁宗英,侯继申,等.大蒜素干预下大鼠血清对食管癌EC109细胞增殖及凋亡的影响[J].中国煤炭工业医学杂志,2015,18(11):1897-1900.
11 Rawla P,Barsouk A.Epidemiology of gastric cancer:global trends,risk factors and prevention[J].Prz Gastroenterol,2019,14(1):26-38.
12 Zhang X,Zhu Y,Duan W,et al.Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway[J].Mol Med Rep,2015,11(4):2755-2760.
13 吴淑芬,李志晋.大蒜素抑制内质网自噬影响胃癌SGC-7901细胞增殖和凋亡的研究[J].肿瘤药学,2019,9(2):226-230.
14 Torre LA,Siegel RL,Ward EM,et al.Global cancer incidence and mortality rates and trends-an update[J].Cancer Epidemiol Biomarkers Prev,2016,25(1):16-27.
15 Wang CH,Wey KC,Mo LR,et al.Current trends and recent advances in diagnosis,therapy,and prevention of hepatocellular carcinoma[J].Asian Pac J Cancer Prev,2015,16(9):3595-3604.
16 Kulik LM,Chokechanachaisakul A.Evaluation and management of hepatocellular carcinoma[J].Clin Liver Dis,2015,19(1):23-43.
17 Zou X,Liang J,Sun J,et al.Allicin sensitizes hepatocellular cancer cells to anti-tumor activity of 5-fluorouracil through ROS-mediated mitochondrial pathway[J].J Pharmacol Sci,2016,131(4):233-240.
18 Chu YL,Ho CT,Chung JG,et al.Allicin induces p53-mediated autophagy in Hep G2 human liver cancer cells[J].J Agric Food Chem,2012,60(34):8363-8371.
19 Sui X,Jin L,Huang X,et al.p53 signaling and autophagy in cancer:a revolutionary strategy could be developed for cancer treatment[J].Autophagy,2011,7(6):565-571.
20 Ryan KM.p53 and autophagy in cancer:guardian of the genome meets guardian of the proteome[J].Eur J Cancer,2011,47(1):44-50.
21 Kim J,Kundu M,Viollet B,et al.AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1[J].Nat Cell Biol,2011,13(2):132-141.
22 吴万龙,彭兵.胰腺癌流行病学及危险因素[J].中国普外基础与临床杂志,2019,26(3):1-5.
23 Zeng H,Chen W,Zheng R,et al.Changing cancer survival in China during 2003-15:a pooled analysis of 17 population-based cancer registries[J].Lancet Glob Health,2018,6(5):555-567.
24 Wang CJ,Wang C,Han J,et al.Effect of combined treatment with recombinant interleukin-2 and allicin on pancreatic cancer[J].Mol Biol Rep,2013,40(12):6579-6585.
25 Hamaoka M,Kozaka K,Matsui O,et al.Early detection of intrahepatic cholangiocarcinoma[J].Jpn J Radiol,2019,37(10):669-684.
26 Saha SK,Zhu AX,Fuchs CS,et al.Forty-year trends in cholangiocarcinomaincidence in the U S.intrahepatic disease on the rise[J].Oncologist,2016,21(5):594-609.
27 Khan SA,Taylor-Robinson SD,Toledano MB,et al.Changing international trends in mortality rates for liver,biliary and pancreatic tumours[J].J Hepatol,2002,37(6):806-813.
28 DeOliveira ML,Cunningham SC,Cameron JL,et al.Cholangiocarcinoma:thirty-one-year experience with 564 patients at a single institution[J].Ann Surg,2007,245(5):755-762.
29 Everhart JE,Ruhl CE.Burden of digestive diseases in the United States Part III:liver,biliary tract,and pancreas[J].Gastroenterology,2009,136(4):1134-1144.
30 Chen H,Zhu B,Zhao L,et al.Allicin inhibits proliferation and invasion in vitro and in vivo via SHP-1-mediated STAT3 signaling in cholangiocarcinoma[J].Cell Physiol Biochem,2018,47(2):641-653.
31 Keum N,Giovannucci E.Global burden of colorectal cancer:emerging trends,risk factors and prevention strategies[J].Nat Rev Gastroenterol Hepatol,2019,16(12):567-571.
32 Bat-Chen W,Golan T,Peri I,et al.Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2[J].Nutr Cancer,2010,62(7):947-957.

[1]	邵佳月, 孙秀威. 大蒜素联合5-FU对结肠癌HT-29细胞凋亡的影响及机制[J]. 实用肿瘤学杂志, 2018, 32(4): 289-292.
[2]	吕福莲, 高翔综述, 金艾顺审校. 肿瘤干细胞潜在标志物DCLK1在消化道恶性肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2015, 29(5): 458-461.
[3]	姚淞元,吴永梅. TAP检测在消化道肿瘤诊断和预后判断中的意义[J]. 实用肿瘤学杂志, 2015, 29(2): 122-126.
[4]	曹春晓综述, 王玉华审校. PPARγ及罗格列酮与消化系统肿瘤[J]. 实用肿瘤学杂志, 2009, 23(6): 579-581.
[5]	林朝春;叶珠赛;孙秀琴. 消化道肿瘤抑郁患者对化疗不良反应的影响与护理对策[J]. 实用肿瘤学杂志, 2008, 22(05): 468-469.
[6]	黄彩萍;林朝春;叶珠赛. 奥沙利铂治疗消化道肿瘤的临床观察与护理[J]. 实用肿瘤学杂志, 2008, 22(01): 55-56.
[7]	方志坚;李德津. 以贫血为首发症状消化道肿瘤94例临床分析[J]. 实用肿瘤学杂志, 2002, 16(02): 133-134.
[8]	刘德华;华阳;李森;罗娅红. 62例消化道肿瘤的肝转移瘤的介入治疗[J]. 实用肿瘤学杂志, 2001, 15(03): 232-233.

大蒜素抑制消化道肿瘤细胞增殖作用的研究进展

Research progress of diallyltrisulfide in inhibiting proliferation of digestive tract tumor cells

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 8

编辑推荐

Metrics

本文评价