TPX2与肿瘤关系的研究进展

doi:10.11904/j.issn.1002-3070.2021.01.017

摘要/Abstract

摘要： 基因组不稳定是癌症的标志。XKlP2靶蛋白(Targeting protein for Xenopus kinesin-like protein 2,TPX2)在细胞有丝分裂过程中参与纺锤体的形成。TPX2 的异常表达可导致中心体异常扩增、纺锤体发生异常,进而影响染色体组的稳定性,细胞发生恶性转化。近年来研究证实,TPX2在多种恶性肿瘤中过表达,且与肿瘤发生发展及预后密切相关。抑制TPX2表达,可抑制肿瘤的增殖及侵袭。因此,TPX2有望成为肿瘤诊断和判断预后的重要标志物,以及肿瘤治疗的新方向。

关键词: TPX2, 肿瘤, 过表达

Abstract: Genome instability is a hallmark of cancer.Targeting protein for xenopus kinesin-like protein 2(TPX2)is involved in the spindle formation during cell mitosis.The abnormal expression of TPX2 can lead to abnormal centrosome amplification and spindle abnormality,and then affect the stability of the genome and malignant transformation of cells.In recent years,studies have confirmed that TPX2 is overexpressed in a variety of malignant tumors,and is closely related to the occurrence,development and prognosis of cancer.Inhibition of TPX2 expression can inhibit tumor proliferation and invasion.Therefore,TPX2 is expected to become an important marker of tumor diagnosis and prognosis,as well as a new direction of tumor treatment.

Key words: TPX2, Tumor, Overexpression

中图分类号:

R730

王庆亮,赵艳峰,蒋燕(综述),姜格宁(审校). TPX2与肿瘤关系的研究进展[J]. 实用肿瘤学杂志, 2021, 35(1): 83-86.

WANG Qingliang,ZHAO Yanfeng,JIANG Yan,JIANG Gening. Research progress on the relationship between TPX2 and tumor[J]. Journal of Practical Oncology, 2021, 35(1): 83-86.

参考文献

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