外泌体与妇科恶性肿瘤相关性的最新研究进展

doi:10.11904/j.issn.1002-3070.2020.06.017

实用肿瘤学杂志 ›› 2020, Vol. 34 ›› Issue (6): 571-575.doi: 10.11904/j.issn.1002-3070.2020.06.017

外泌体与妇科恶性肿瘤相关性的最新研究进展

宋家羽, 冯越, 王棹综述, 张云艳审校

哈尔滨医科大学附属肿瘤医院(哈尔滨 150081)

收稿日期:2020-03-15 修回日期:2020-06-10 出版日期:2020-12-28 发布日期:2020-12-23
通讯作者: 张云艳,E-mail:zhangyunyan1972@163.com
作者简介:宋家羽,女,(1992-),硕士研究生,从事妇科肿瘤病因学的研究。

The latest research progress of the correlation between exosomes and gynecological malignant tumor

SONG Jiayu, FENG Yue, WANG Zhao, ZHANG Yunyan

Harbin Medical University Cancer Hospital,Harbin 150081,China

Received:2020-03-15 Revised:2020-06-10 Online:2020-12-28 Published:2020-12-23

摘要/Abstract

摘要： 妇科恶性肿瘤是影响女性健康、降低女性生活质量的恶性疾病,并逐渐呈年轻化趋势。由于大多数妇科恶性肿瘤的早期临床表现不明显,因此很多患者就诊时已达中晚期。妇科恶性肿瘤患者,术后5年生存率与患者初次诊断时间呈正相关,所以其早诊断早治疗尤为重要。近年来多项研究表明外泌体积极参与了妇科恶性肿瘤的发生、侵袭、转移和免疫反应的调节,因此外泌体对于肿瘤的早期诊断、治疗及预后都提供了新的研究思路。本文就外泌体作为妇科恶性肿瘤的早期筛查标志物及其对临床治疗中抗肿瘤药物的研发方面进行综述。

关键词: 外泌体, 妇科恶性肿瘤, 诊断标志物, 靶向治疗

Abstract: Gynecological malignant tumors are malignant diseases that affect women′s health and reduce women′s quality of life.They are gradually becoming younger.Because the early clinical manifestations of most gynecological malignancies are not obvious,many patients have reached the mid-advanced stage at the time of treatment.In patients with gynecological malignant tumors,the 5-year survival rate after surgery is positively correlated with the time of the patient′s initial diagnosis,so early diagnosis and early treatment are particularly important.In recent years,a number of studies have shown that exosomes are actively involved in the occurrence,invasion,metastasis and immune response of gynecological malignant tumors.Therefore,exosomes provide new research ideas for the early diagnosis,treatment and prognosis of tumors.This article reviews exosomes as an early screening marker for gynecological malignancies and the development of antitumor drugs in the clinical treatment.

Key words: Exosomes, Gynecological malignant tumors, Diagnostic markers, Targeted therapy

中图分类号:

R737.3

宋家羽, 冯越, 王棹, 张云艳. 外泌体与妇科恶性肿瘤相关性的最新研究进展[J]. 实用肿瘤学杂志, 2020, 34(6): 571-575.

SONG Jiayu, FENG Yue, WANG Zhao, ZHANG Yunyan. The latest research progress of the correlation between exosomes and gynecological malignant tumor[J]. Journal of Practical Oncology, 2020, 34(6): 571-575.

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外泌体与妇科恶性肿瘤相关性的最新研究进展

The latest research progress of the correlation between exosomes and gynecological malignant tumor

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