HPV蛋白、miRNAs和外泌体在宫颈癌炎症作用中的研究进展

doi:10.11904/j.issn.1002-3070.2020.03.018

摘要/Abstract

摘要： 人乳头瘤状病毒(Human papilloma virus,HPV)感染是导致宫颈癌发生发展最重要的危险因素。目前有研究表明,HPV蛋白直接或间接参与慢性炎症发生,进而促进肿瘤发展。非编码RNA(miRNAs)是基因表达的调控因子,也是炎症通路的关键参与者,miRNAs的异常表达可能与宫颈癌的炎性反应有关。外泌体是细胞分泌到细胞外的囊泡,这些囊泡可以作为运载体与受体结合。最近研究发现外泌体参与了炎症过程,影响免疫反应。在这篇综述中,我们讨论了HPV蛋白、miRNAs和外泌体在宫颈癌炎症作用中的研究进展。

关键词: 宫颈癌, 炎症因子, 人乳头瘤状病毒, microRNAs, 外泌体

Abstract: Human papilloma virus(HPV)infection is the most important risk factor for cervical cancer.At present,many studies have shown that HPV protein is directly or indirectly involved in the occurrence of chronic inflammation,thereby promoting tumor development.Non-coding RNA(microRNA;miRNAs)is a regulator of gene expression and a key player in the inflammatory pathway.The abnormal expression of miRNAs may be related to the inflammatory response of cervical cancer.Exosomes are vesicles secreted by cells from the outside of cells,and these vesicles can act as a carrier to bind to the receptor.Recent studies have found that exosomes are involved in the inflammatory process and affect the immune response.In this review,we discuss the research progress of HPV proteins,miRNAs and exosomes in the inflammatory effects of cervical cancer.

Key words: Cervical cancer, Inflammatory Factors, HPV, microRNAs, Exosomes

中图分类号:

R737.33

曹宁, 夏百荣, 娄阁. HPV蛋白、miRNAs和外泌体在宫颈癌炎症作用中的研究进展[J]. 实用肿瘤学杂志, 2020, 34(3): 282-285.

CAO Ning,XIA Bairong,LOU Ge. Research progress of HPV proteins,miRNAs and exosomes in the inflammation of cervical cancer[J]. Journal of Practical Oncology, 2020, 34(3): 282-285.

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链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2020.03.018

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2020/V34/I3/282

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