关键词: 肝癌, 发病率, 死亡率, 年度变化百分比, 云南

Abstract: Objective The aims of this study were to analyze the incidence and mortality of liver cancer in Yunnan province in 2016 and the change trend from 2011 to 2016,and to provide a reference for the prevention and control of liver cancer. Methods Based on the data of tumor registration and related population in Yunnan province from 2011 to 2016,Excel 2007 and IARCcrgTools 2.05 software released by IARC were used to review and evaluate the data.SAS 9.4 and Excel 2007 were used to calculated crude incidence,mortality,age-standardized rate,cumulative rate of 0~74 years old,and truntated age-standarized rate(TASR)of 35~64 years old of liver cancer.Joinpoint 4.8 was used to calculate annual percentage change(APC)and its 95% confidence interval to comprehensively analyze the incidence and mortality of liver cancer. Results In 2016,the crude incidence of liver cancer in Yunnan province was 21.74/100,000,accounting for 10.21% of all malignant tumors,ranking fourth in the incidence of malignant tumors.The crude mortality was 19.56/100,000,accounting for 15.37% of malignant tumors,ranking second death in malignant tumors.The crude incidence and crude mortality,the China standard rate,the world standard rate,the cumulative rate(0~74 years old)and TASR(35~64 years old)of males were higher than those of females.The incidence and mortality of liver cancer in men,the Chinese standard rate,the World standard rate,the cumulative rate(0~74 years old)and the TASR(35~64 years old)were higher than women.The incidence and mortality of liver cancer in rural areas,the world standard rate,the cumulative rate(0~74 years old)and TASR(35~64 years old)were higher than those in urban areas.The incidence and mortality of liver cancer from 2011 to 2016 in Yunnan province both showed an upward trend(APC=3.90% and 5.60%;P＜ 0.05);The incidence and mortality both in rural areas and urban areas showed an upward trend(APC=4.60% and 6.50%;P＜0.05);The mortality of Chinese standard in males showed an upward trend(APC=5.40%,P＜0.05),and the rising trend of male Chinese standard mortality in urban areas was higher than that of females(APC=6.60% and 6.20%;P＜0.05). Conclusion In 2016,the incidence and death level of liver cancer in Yunnan province are lower than the national average,men are higher than women,and rural areas are higher than urban areas.The incidence and mortality of liver cancer from 2011 to 2016 are on the rise,and the incidence and death characteristics of liver cancer should be further targeted,strengthened prevention and control work.

Key words: Liver cancer;Incidence;Mortality;Annual percentage change;Yunnan