辽宁省三城市居民胃癌10年生存率及其影响因素分析

doi:10.11904/j.issn.1002-3070.2021.04.009

实用肿瘤学杂志 ›› 2021, Vol. 35 ›› Issue (4): 339-343.doi: 10.11904/j.issn.1002-3070.2021.04.009

辽宁省三城市居民胃癌10年生存率及其影响因素分析

穆慧娟¹, 李海娜², 吕艺³, 孙丽华⁴, 王丽娟⁵, 礼彦侠¹, 于飞⁶, 潘国伟⁶, 刘莉¹

1.辽宁省疾病预防控制中心(沈阳 110005);
2.本溪市疾病预防控制中心;
3.沈阳市疾病预防控制中心;
4.辽宁省肿瘤医院;
5.鞍山市疾病预防控制中心;
6.中国医科大学

收稿日期:2021-01-29 修回日期:2021-03-12 发布日期:2021-08-24
通讯作者: 刘莉,E-mail:liulilncdc@163.com
作者简介:穆慧娟,女,(1980-),硕士,副主任医师,从事慢性病预防与控制的研究。
基金资助:
辽宁省兴辽英才计划项目(编号:XLYC1802131);辽宁省自然科学基金指导计划(编号:20180550495)

Analysis for 10-year survival rate of gastric cancer and its influencing factors among residents in three cities of Liaoning province

MU Huijuan¹, LI Haina², LV Yi³, SUN Lihua⁴, WANG Lijuan⁵, LI Yanxia¹, YU Fei⁶, PAN Guowei⁶, LIU Li¹

1. Liaoning Center for Disease Control and Prevention,Shenyang 110005,China;
2. Benxi Center for Disease Control and Prevention;
3. Shenyang Center for Disease Control and Prevention;
4. Cancer Hospital of China Medical University;
5. Anshan Center for Disease Control and Prevention;
6. China Medical University

Received:2021-01-29 Revised:2021-03-12 Published:2021-08-24

摘要/Abstract

摘要： 目的分析辽宁省3城市居民胃癌10年生存状况及其影响因素。方法对辽宁省3城市2000—2002年肿瘤发病报告数据库随机抽取的400例胃癌进行主动随访,获得患者诊疗和生存状况。采用寿命表法计算观察生存率(Observed survival rate,OSR),应用EdererⅡ方法计算相对生存率(Relative survival rate,RSR)。多因素Cox模型分析生存影响因素。结果辽宁省3城市居民胃癌10年OSR、RSR和T₅₀分别为14.3%、19.1%、12.3个月。Ⅰ~Ⅱ期病例的10年OSR、RSR和T₅₀(41.6%、53.7%和69.0个月)均显著高于Ⅲ期(9.1%、14.1%和14.7个月)和Ⅳ期(3.0%、4.1%和6.1个月)(P＜0.05)。手术治疗病例10年OSR、RSR和T₅₀(20.8%、27.7%和20.8个月)显著高于未接受手术治疗病例(2.6%、3.9%和4.9个月)(P＜0.05);0~64岁组10年OSR、RSR和T₅₀(21.1%、23.2%和14.0个月)均显著高于65+岁组(8.9%、15.7%和10.4个月)(P＜0.05);男性与女性10年OSR、RSR及T₅₀均无统计学差异。多因素分析结果显示,诊断分期、治疗方式和年龄对胃癌10年相对生存率有显著影响。结论辽宁省3城市居民胃癌10年相对生存率(19.1%)低于欧美(25.4%~30.7%)及韩国(48.7%)等经济发达国家同期水平 ,早诊断率和规范性诊疗率低可能是主要原因。

关键词: 胃癌, 十年生存率, 相对生存率, 观察生存率, 影响因素

Abstract: Objective The aim of this study was to analyze 10 years survival status of gastric cancer and its influencing factors in three cities of Liaoning province. Methods Four hundred cases of gastric cancer randomly selected from the tumor incidence report database in three cities of Liaoning province from 2000 to 2002 were actively followed up to obtain the diagnosis,treatment and survival status of the patients.The life table method was used to calculate the observed survival rate(OSR),and the Ederer II method was used to calculate the relative survival rate(RSR).The multivariate Cox model was used to analyze the factors affecting survival. Results The 10-year OSR,RSR and T₅₀ of gastric cancer in the three cities of Liaoning province were 14.3%,19.1%,and 12.3 months,respectively.The 10-year OSR,RSR and T₅₀(41.6%,53.7% and 69.0 months)of stage Ⅰ~Ⅱ cases were significantly higher than those of stage Ⅲ(9.1%,14.1% and 14.7 months)and stage Ⅳ(3.0%,4.1% and 6.1 months).The 10-year OSR,RSR and T₅₀(20.8%,27.7% and 20.8 months)of patients treated with surgery were significantly higher than those of non-operative cases(2.6%,3.9% and 4.9 months).The 10-year OSR,RSR and T₅₀(21.1%,23.2% and 14.0 months)in the 0~64 years old group were significantly higher than those in the 65+ years old group(8.9%,15.7% and 10.4 months).There were no significant differences in the 10-year OSR,RSR and T₅₀ between males and females.The results of multivariate analysis showed that diagnosis staging,treatment methods and age had significant impact on the 10-year relative survival rate of gastric cancer. Conclusion The 10-year relative survival rate of gastric cancer(19.1%)in three cities of Liaoning province was lower than that of Europe and America(25.4%~30.7%)and Korea(48.7%)in the same period.The low rate of early diagnosis and standardized diagnosis and treatment may be the main reasons.

Key words: Gastric cancer, 10-year survival rate, Relative survival rate, Observed survival rate, Influence factor

中图分类号:

R735.2

穆慧娟, 李海娜, 吕艺, 孙丽华, 王丽娟, 礼彦侠, 于飞, 潘国伟, 刘莉. 辽宁省三城市居民胃癌10年生存率及其影响因素分析[J]. 实用肿瘤学杂志, 2021, 35(4): 339-343.

MU Huijuan, LI Haina, LV Yi, SUN Lihua, WANG Lijuan, LI Yanxia, YU Fei, PAN Guowei, LIU Li. Analysis for 10-year survival rate of gastric cancer and its influencing factors among residents in three cities of Liaoning province[J]. Journal of Practical Oncology, 2021, 35(4): 339-343.

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辽宁省三城市居民胃癌10年生存率及其影响因素分析

Analysis for 10-year survival rate of gastric cancer and its influencing factors among residents in three cities of Liaoning province

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