热休克蛋白90在食管鳞癌中的表达及临床意义

doi:10.11904/j.issn.1002-3070.2021.06.017

实用肿瘤学杂志 ›› 2021, Vol. 35 ›› Issue (6): 572-575.doi: 10.11904/j.issn.1002-3070.2021.06.017

热休克蛋白90在食管鳞癌中的表达及临床意义

孟迪, 徐倩文综述, 孙秀威审校

哈尔滨医科大学附属肿瘤医院(哈尔滨 150081)

收稿日期:2020-11-26 修回日期:2021-02-04 出版日期:2021-12-28 发布日期:2021-12-17
通讯作者: 孙秀威,E-mail:sun-xiuwei@163.com
作者简介:孟迪,女,(1994-),硕士研究生,从事消化道肿瘤基础和临床的研究。

Expression and clinical significance of heat shock protein 90 in esophageal squamous cell carcinoma

MENG Di, XU Qianwen, SUN Xiuwei

Harbin Medical University Cancer Hospital,Harbin 150081,China

Received:2020-11-26 Revised:2021-02-04 Online:2021-12-28 Published:2021-12-17

摘要/Abstract

摘要： 食管鳞状细胞癌(Esophagus squamous cell carcinoma,ESCC)是我国食管癌的主要病理分型,它起病隐匿、转移速度快,且给予治疗时产生耐药的速度快,导致预后不理想。热休克蛋白90(Heat shock protein 90,HSP90)调控的众多下游蛋白参与细胞的增殖等过程,所以在恶性肿瘤的发生发展中常扮演重要角色。越来越多的研究证实HSP90在多种恶性肿瘤中高表达并可影响肿瘤耐药性。近年来,对HSP90在ESCC中相关作用的探索也收获了许多值得关注的成果,本文将对HSP90在ESCC中的表达及临床意义做一综述。

关键词: 食管鳞状细胞癌, 热休克蛋白90, 热休克蛋白抑制剂

Abstract: Esophageal squamous cell carcinoma(ESCC)is the main pathological type of esophageal carcinoma in China.It is characterized by an insidious onset,rapid metastasis,and rapid drug resistance during treatment,resulting in an unsatisfactory prognosis.Many downstream proteins regulated by heat shock protein 90(HSP90)are involved in cell proliferation and other processes,so they often play an important role in the occurrence and development of malignant tumors.More and more studies have confirmed that HSP90 is highly expressed in a variety of malignant tumors and can affect tumor resistance.In recent years,the exploration relevant role of HSP90 in ESCC has also yielded many achievements worthy of attention.This article will review the expression and clinical significance of HSP90 in ESCC.

Key words: Esophageal squamous cell carcinoma, Heat shock protein 90, Heat shock protein inhibitors

中图分类号:

R735.1

孟迪, 徐倩文, 孙秀威. 热休克蛋白90在食管鳞癌中的表达及临床意义[J]. 实用肿瘤学杂志, 2021, 35(6): 572-575.

MENG Di, XU Qianwen, SUN Xiuwei. Expression and clinical significance of heat shock protein 90 in esophageal squamous cell carcinoma[J]. Journal of Practical Oncology, 2021, 35(6): 572-575.

0
/ / 推荐

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2021.06.017

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2021/V35/I6/572

参考文献

1 Bray F,Ferlay J,Soerjomataram I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.
2 McGuire S.World Cancer Report 2014.Geneva,Switzerland:World Health Organization,International Agency for Research on Cancer,WHO Press,2015[J].Adv Nutr,2016,7(2):418-419.
3 Short MW,Burgers KG,Fry VT.Esophageal cancer[J].Am Fam Physician,2017,95(1):22-28.
4 Zhang L,Ma J,Han Y,et al.Targeted therapy in esophageal cancer[J].Expert Rev Gastroenterol Hepatol,2016,10(5):595-604.
5 Hoter A,El-Sabban ME,Naim HY.The HSP90 family:structure,regulation,function,and implications in health and disease[J].Int J Mol Sci,2018,19(9):2560.
6 赵凌云,齐鲁楠,游雪梅.热休克蛋白70在肝细胞癌中的研究进展[J].实用肿瘤学杂志,2017,31(6):528-532.
7 Liu K,Kang M,Li J,et al.Prognostic value of the mRNA expression of members of the HSP90 family in non-small cell lung cancer[J].Exp Ther Med,2019,17(4):2657-2665.
8Dong L,Xue L,Zhang C,et al.HSP90 interacts with HMGCR and promotes the progression of hepatocellular carcinoma[J].Mol Med Rep,2019,19(1):524-532.
9 Taipale M,Jarosz DF,Lindquist S.HSP90 at the hub of protein homeostasis:emerging mechanistic insights[J].Nat Rev Mol Cell Biol,2010,11(7):515-528.
10 Trop-Steinberg S,Azar Y.Is Myc an important biomarker? Myc expression in immune disorders and cancer[J].Am J Med Sci,2018,355(1):67-75.
11 Dang CV,O′Donnell KA,Zeller KI,et al.The c-Myc target gene network[J].Semin Cancer Biol,2006,16(4):253-264.
12 Lian Y,Niu X,Cai H,et al.Clinicopathological signifificance of c-MYC in esophageal squamous cell carcinoma[J].Tumour Biol,2017,39(7):1010428317715804.
13 Wang J,Liu Z,Wang Z,et al.Targeting c-Myc:JQ1 as a promising option for c-Myc-amplifified esophageal squamous cell carcinoma[J].Cancer Lett,2018,419:64-74.
14 Lee J,Zhang LL,Wu W,et al.Activation of MYC,a bona fide client of HSP90,contributes to intrinsic ibrutinib resistance in mantle cell lymphoma[J].Blood Adv,2018,2(16):2039-2051.
15 Guan L,Zou Q,Liu Q,et al.HSP90 inhibitor ganetespib(STA-9090)inhibits tumor growth in c-Myc-dependent esophageal squamous cell carcinoma[J].Onco Targets Ther,2020,13:2997-3011.
16 Peng X,Sun Z,Kuang P,et al.Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment[J].Eur J Med Chem,2020,208:112831.
17 Wang XX,Wan RZ,Liu ZP.Recent advances in the discovery of potent and selective HDAC6 inhibitors[J].Eur J Med Chem,2018,143:1406-1418.
18Aldana-Masangkay GI,Sakamoto KM.The role of HDAC6 in cancer[J].J Biomed Biotechnol,2011,2011:875824.
19Rao R,Fiskus W,Yang Y,et al.HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells[J].Blood,2008,112(5):1886-1893.
20 Tao H,Chen YY,Sun ZW,et al.Silence of HDAC6 suppressed esophageal squamous cell carcinoma proliferation and migration by disrupting chaperone function of HSP90[J].J Cell Biochem,2018,119(8):6623-6632.
21 Lu J,Getz G,Miska EA,et al.MicroRNA expression profifiles classify human cancers[J].Nature,2005,435(7043):834-838.
22 Mishra S,Yadav T,Rani V.Exploring miRNA based approaches in cancer diagnostics and therapeutics[J].Crit Rev Oncol Hematol,2016,98:12-23.
23 Volinia S,Calin GA,Liu CG,et al.A microRNA expression signature of human solid tumors defifines cancer gene targets[J].Proc Natl Acad Sci U S A,2006,103(7):2257-2261.
24 Jiang Y,Duan Y,Zhou H.MicroRNA-27a directly targets KRAS to inhibit cell proliferation in esophageal squamous cell carcinoma[J].Oncol Lett,2015,9(1):471-477.
25 Kariya A,Furusawa Y,Yunoki T,et al.A microRNA-27a mimic sensitizes human oral squamous cell carcinoma HSC-4 cells to hyperthermia through downregulation of Hsp110 and Hsp90[J].Int J Mol Med,2014,34(1):334-340.
26 Wang X,An D,Liu X,et al.MicroRNA-27a downregulates the expression of Hsp90 and enhances the radiosensitivity in esophageal squamous cell carcinoma[J].Onco Targets Ther,2019,12:5967-5977.
27 Galluzzi L,Vitale I,Michels J,et al.Systems biology of cisplatin resistance:past,present and future[J].Cell Death Dis,2014,5(5):e1257.
28 Sun Y,Zhai L,Ma S,et al.Down-regulation of RIP3 potentiates cisplatin chemoresistance by triggering HSP90-ERK pathway mediated DNA repair in esophageal squamous cell carcinoma[J].Cancer Lett,2018,418:97-108.
29 Wang S,Du Z,Luo J,et al.Inhibition of heat shock protein 90 suppresses squamous carcinogenic progression in a mouse model of esophageal cancer[J].J Cancer Res Clin Oncol,2015,141(8):1405-1416.
30 Revathidevi S,Munirajan AK.Akt in cancer:mediator and more[J].Semin Cancer Biol,2019,59:80-91.
31 Yan H,Li B,Fan T,et al.Clinical significance of serum dynamics of HSP90a level in esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy[J].Cancer Biomark,2017,19(2):185-192.

[1]	郝贺, 李幸, 吴玲彦, 郭晓金, 曹静, 杨春旺, 张晓, 汪治宇. PD-1、CTLA-4、BLTA在食管鳞状细胞癌患者外周血中的表达及临床意义[J]. 实用肿瘤学杂志, 2018, 32(4): 303-308.
[2]	高红军, 岳志刚, 周艳秋, 许慧, 段志玲, 郑朝旭. 肿瘤相关抗原HSC70在食管癌中的鉴定与表达研究[J]. 实用肿瘤学杂志, 2012, 26(2): 137-140.

热休克蛋白90在食管鳞癌中的表达及临床意义

Expression and clinical significance of heat shock protein 90 in esophageal squamous cell carcinoma

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 2

编辑推荐

Metrics

本文评价