基于铁死亡的纳米联合疗法在恶性肿瘤治疗中的研究进展

doi:10.11904/j.issn.1002-3070.2022.05.007

实用肿瘤学杂志 ›› 2022, Vol. 36 ›› Issue (5): 429-434.doi: 10.11904/j.issn.1002-3070.2022.05.007

基于铁死亡的纳米联合疗法在恶性肿瘤治疗中的研究进展

王钦¹, 刘军杰¹, 陆秀鑫¹, 吴雅菲² 综述, 张文皓¹ 审校

1.广西医科大学附属肿瘤医院超声科(南宁 530021);
2.广西医科大学第一附属医院超声科

收稿日期:2022-06-05 修回日期:2022-08-29 出版日期:2022-10-28 发布日期:2022-11-10
通讯作者: 张文皓,E-mail:zwh836@163.com
作者简介:王钦,女,(1996-),硕士研究生,从事超声诊断方向的研究。
基金资助:
国家自然科学基金资助项目(编号:82160341);广西自然科学基金项目(编号:2022GXNSFDA035060)

Research progress of nanocombination therapy based on ferroptosis in the treatment of malignant tumors

WANG Qin¹, LIU Junjie¹, LU Xiuxin¹, WU Yafei², ZHANG Wenhao¹

1. Department of Medical Ultrasound,Guangxi Medical University Cancer Hospital,Nanning 530021,China;
2. Department of Medical Ultrasound,The First Affiliated Hospital of Guangxi Medical University

Received:2022-06-05 Revised:2022-08-29 Online:2022-10-28 Published:2022-11-10

摘要/Abstract

摘要： 铁死亡作为一种有潜力的恶性肿瘤治疗策略,日益引起广泛关注。铁死亡是一种铁依赖的调节性细胞死亡方式,其典型特征为细胞内活性氧的蓄积和脂质过氧化。随着纳米技术和生物材料技术的快速发展,多功能纳米制剂介导的铁死亡联合疗法在肿瘤诊断与治疗上显示出巨大的临床应用前景。本文就纳米制剂诱导的铁死亡作用机制及基于铁死亡的联合抗肿瘤疗法的最新研究进展进行综述,并总结了铁死亡疗法在临床肿瘤治疗中的应用前景与挑战,以期为发展新型高效的抗肿瘤策略提供新思路。

关键词: 铁死亡, 恶性肿瘤, 纳米制剂, 联合疗法

Abstract: As a potential treatment strategy for malignant tumors,ferroptosis has attracted widespread attention.Ferroptosis is an iron-dependent regulatory cell death that is typically characterized by the accumulation of intracellular reactive oxygen species and lipid peroxidation.With the rapid development of nanotechnology and biomaterial technology,multifunctional nanoformulation-mediated ferroptosis combined therapy shows great clinical application prospects in tumor diagnosis and treatment.This article reviews the mechanism of nano-formulation-induced ferroptosis and the latest research progress of ferroptosis-based combined antitumor therapy,and summarizes the application prospects and challenges of ferroptosis in clinical tumor treatment,expecting new ideas for tumor strategies to develop new and efficient anti-cancer drugs.

Key words: Ferroptosis, Malignant tumor, Nanomaterials, Combination therapy

中图分类号:

R914

王钦, 刘军杰, 陆秀鑫, 吴雅菲, 张文皓. 基于铁死亡的纳米联合疗法在恶性肿瘤治疗中的研究进展[J]. 实用肿瘤学杂志, 2022, 36(5): 429-434.

WANG Qin, LIU Junjie, LU Xiuxin, WU Yafei, ZHANG Wenhao. Research progress of nanocombination therapy based on ferroptosis in the treatment of malignant tumors[J]. Journal of Practical Oncology, 2022, 36(5): 429-434.

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http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2022/V36/I5/429

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基于铁死亡的纳米联合疗法在恶性肿瘤治疗中的研究进展

Research progress of nanocombination therapy based on ferroptosis in the treatment of malignant tumors

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