乙肝病毒感染性肝癌经TACE后Caspase-3与FAK的表达及意义

doi:10.3969/j.issn.1002-3070.2011.01.014

实用肿瘤学杂志 ›› 2011, Vol. 25 ›› Issue (1): 49-52.doi: 10.3969/j.issn.1002-3070.2011.01.014

乙肝病毒感染性肝癌经TACE后Caspase-3与FAK的表达及意义

王惠文, 刘瑞宝, 刘岩, 沈海洋

哈尔滨医科大学附属第三医院介入科(哈尔滨 150081)

收稿日期:2010-11-02 出版日期:2011-01-25 发布日期:2012-02-21
通讯作者: 刘瑞宝,E-mail:ruibaoliu@hotmail.com
作者简介:王惠文,男,(1984-),硕士在读,从事腹部肿瘤介入治疗

The expression and significance of Caspase-3 and FAK in hepatocarcinoma infected with Hepatitis B Virus after transcatheter arterial chemoembolization

WANG Huiwen,LIU Ruibao,LIU Yan,SHEN Haiyang

Department of Intervention,the Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081

Received:2010-11-02 Online:2011-01-25 Published:2012-02-21

摘要/Abstract

摘要：

目的探讨乙肝病毒感染性肝癌经TACE后Caspase-3与FAK的表达及意义。方法收集我院行TACE治疗后外科手术切除的肝癌组织标本38份,其中HBV感染者27份,无HBV感染者11份,采用免疫组化SP法检测残癌组织中Caspase-3与FAK的表达情况。结果 HBV感染组中Caspase-3与FAK的阳性表达率分别为22.2%和81.5%,未感染组中阳性率分别为63.6%和36.4%,差异有统计学意义(P=0.024;P=0.017)。HBV感染组中Caspase-3与FAK存在显著负相关关系(r=-0.433,P=0.020)。结论 HBV 感染性肝癌较非HBV感染性肝癌Caspase-3表达下调,FAK表达上调,乙肝病毒影响TACE的治疗疗效。

关键词: 乙肝病毒, 肝癌, 天冬氨酸特异性半胱氨酸蛋白酶3, 局部黏着斑激酶

Abstract:

Objective To investigate the expression and significance of Caspase-3 and FAK in hepatocarcinoma infected with Hepatitis B Virus after TACE.Methods To collect thirty-eight surgical specimens of hepatocarcinoma after TACE,including twenty-seven cases infected with HBV and eleven cases with no HBV.The Caspase-3 and FAK in residual tissues of hepatocarcinoma were detected by using immunohistochemical SP method.Results The positive rate of Caspase-3 and FAK in HBV group were respectively 22.2% and 81.5%,and that of no HBV group were 63.6% and 36.4% respectively.The difference between the two groups was statistically significant(P=0.024;P=0.017).The expression of Caspase-3 and FAK in HBV group was negatively correlated(r=-0.433,P=0.020).Conclusion HBV could suppress the expression of Caspase-3 and up-regulate the expression of FAK.HBV effect the therapeutic effect of TACE.

Key words: HBV, Hepatocarcinoma, Caspase-3, FAK

中图分类号:

R735.7

王惠文, 刘瑞宝, 刘岩, 沈海洋. 乙肝病毒感染性肝癌经TACE后Caspase-3与FAK的表达及意义[J]. 实用肿瘤学杂志, 2011, 25(1): 49-52.

WANG Huiwen,LIU Ruibao,LIU Yan,SHEN Haiyang. The expression and significance of Caspase-3 and FAK in hepatocarcinoma infected with Hepatitis B Virus after transcatheter arterial chemoembolization[J]. PRACTICAL ONCOLOGY JOURNAL, 2011, 25(1): 49-52.

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乙肝病毒感染性肝癌经TACE后Caspase-3与FAK的表达及意义

The expression and significance of Caspase-3 and FAK in hepatocarcinoma infected with Hepatitis B Virus after transcatheter arterial chemoembolization

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