实用肿瘤学杂志 ›› 2013, Vol. 27 ›› Issue (3): 198-201.doi: 10.3969/j.issn.1002-3070.2013.03.002

• 妇科肿瘤专栏 • 上一篇    下一篇

宫颈癌前哨淋巴结研究新进展

吴小华,陈小军   

  1. 复旦大学附属肿瘤医院妇科(上海 200032)
  • 收稿日期:2013-01-07 出版日期:2013-06-28 发布日期:2013-07-04
  • 作者简介:吴小华 医学博士,现任复旦大学附属肿瘤医院妇瘤科主任、教授、博士生导师、主任医师、妇科肿瘤多学科综合治疗首席专家。所领导的科室每年手术治疗浸润性宫颈癌1000余例,根治性放疗宫颈癌500余例。迄今为止已开展的年轻宫颈癌保留生育功能手术130余例,无一例复发;完成了局部晚期宫颈癌新辅助治疗的临床前瞻性研究。先后承担国家自然科学基金面上项目三项,科技部863子课题两项,卫生部课题两项,上海市科委重大课题等妇科肿瘤临床及基础课题的研究多项。近年来,在国内外杂志发表各类论文60余篇,其中通讯作者SCI论文16篇,累计影响因子>50。担任宫颈癌NCCN临床实践指南中国版执笔人。

Update on sentinel lymph node evaluation in cervical cancer

WU Xiaohua,CHEN Xiaojun   

  1. Department of Gynecologic Oncology,Fudan University Shanghai Cancer Center,Shanghai 200032,China
  • Received:2013-01-07 Online:2013-06-28 Published:2013-07-04

摘要: 宫颈癌淋巴结转移状态虽未纳入FIGO分期,但评价淋巴结是否转移不仅可以判断宫颈癌患者的预后,也可作为术后是否需要辅助治疗的依据。早期宫颈癌淋巴结转移率较低,系统淋巴结清扫导致的手术并发症是困扰临床医生的问题,前哨淋巴结活检技术有利于减少不必要的系统淋巴结清扫。该技术在宫颈癌中虽然已有十余年的研究积累,但由于各种原因仍未被临床广泛应用和接受。近几年宫颈癌新的应用策略的提出和新应用方向为宫颈癌前哨淋巴结的临床应用提供了新的契机,本文就宫颈癌前哨淋巴结应用策略新进展做一综述。

Abstract: The International Federation of Gynecology and Obstetrics(FIGO)staging system does not include lymph node status.But in surgically treated patients with early cervical cancer,lymph node metastasis is the most important risk factor for recurrence and death.Accurate knowledge of lymph node status is essential to tailor adjuvant treatment.In operable early stage cervical cancer,prevalence of lymph node metastasis is low.It suggests that majority of these patients may undergo lymphadenectmy for no direct benefit while being subjected to the potential risk of associated morbidities.Over the last decade,the use of sentinel lymph node(SLN)mapping procedure in cervical cancer has been studied by multiple groups in hundreds of patients.Nevertheless,it has not yet been adopted as a standard of care.Recently,two institutes developed different systematic algorithms for SLN mapping in cervical cancer with encouraging data from their studies.This review will focus on these algorithms which may give new approaches to apply SLN in cervical cancer lymph node status evaluation.

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