摘要： 目的探讨可溶性细胞间粘附分子1(Solubleintercellular adhesion molecule,sICAM-1)与胃癌侵袭转移的关系.方法用双抗体夹心法测定53例胃癌患者,20例胃癌前期病变患者及20例正常人血清中sICAM-1水平,并观察胃癌根治术前后患者血清sICAM-1水平的变化.结果胃癌患者血清sICAM-1水平为541.5 ng/ml,明显高于胃癌前期病变患者(306.8 ng/ml)及正常人(294.3 ng/ml)(P＜0.01);I期患者血清sICAM-1水平明显低于Ⅲ期与Ⅳ期患者(P＜0.01或P＜0.05),Ⅲ期与Ⅳ期患者差异无显著性(P＞0.05);胃癌淋巴结未转移患者血清sICAM-1水平(462.8 ng/ml)显著高于正常人(P＜0.01),而胃癌淋巴结转移患者血清sICAM-1水平(556.0ng/ml)又高于淋巴结未转移患者;根治术后患者血清sICAM-1为384.0 ng/ml,比术前(500.0 ng/ml)明显降低(P＜0.01).结论血清sICAM-1与胃癌侵袭转移有关,测定血清sICAM-1对胃癌术前判断病情、估计预后及制订治疗方案具有临床价值.

关键词: 胃肿瘤, 细胞间粘附分子1, 肿瘤转移