MYO10与恶性肿瘤的研究进展

doi:10.11904/j.issn.1002-3070.2021.03.015

实用肿瘤学杂志 ›› 2021, Vol. 35 ›› Issue (3): 273-276.doi: 10.11904/j.issn.1002-3070.2021.03.015

MYO10与恶性肿瘤的研究进展

国昊楠综述, 秦韬审校

桂林医学院附属医院检验科(桂林 541001)

收稿日期:2020-11-30 修回日期:2020-12-18 出版日期:2021-06-28 发布日期:2021-06-22
通讯作者: 秦韬,E-mail:qt811122@163.com
作者简介:国昊楠,女,(1989-),博士研究生,从事肿瘤发生发展遗传机制与临床诊治的研究。
基金资助:
广西医疗卫生适宜技术开发与推广应用项目(编号:S2020113)

Research progress of MYO10 and malignant tumors

GUO Haonan, QIN Tao

Department of Clinical Laboratory,The Affiliated Hospital of Guilin Medical University,Guilin 541001,China

Received:2020-11-30 Revised:2020-12-18 Online:2021-06-28 Published:2021-06-22

摘要/Abstract

摘要： 肌球蛋白X(Myosin X,MYO10)是一种基于肌动蛋白的分子马达,可诱导丝状伪足形成并在体内外促进细胞的迁移过程。近年来多项研究表明MYO10在侵入性伪足形成过程中的异常表达与恶性肿瘤的侵袭和转移密切相关。本文就MYO10生物学功能及在恶性肿瘤发生发展中的研究进展做一综述。

关键词: 肌球蛋白X, 侵入性伪足, 恶性肿瘤, 转移

Abstract: Myosin X(MYO10)is a molecular motor based on actin,which can induce the formation of filopodia and promote cell migration in vitro and in vivo.In recent years,many studies have shown that the abnormal expression of MYO10 in the formation of invasive pseudopodia is closely related to the invasion and metastasis of malignant tumors.This article reviews the biological function of MYO10 and its research progress in the occurrence and development of malignant tumors.

Key words: Myosin X, Invasive pseudopodia, Malignant tumors, Metastasis

中图分类号:

R730.7

国昊楠, 秦韬. MYO10与恶性肿瘤的研究进展[J]. 实用肿瘤学杂志, 2021, 35(3): 273-276.

GUO Haonan, QIN Tao. Research progress of MYO10 and malignant tumors[J]. Journal of Practical Oncology, 2021, 35(3): 273-276.

0
/ / 推荐

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2021.03.015

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2021/V35/I3/273

参考文献

1 Eddy RJ,Weidmann MD,Sharma VP,et al.Tumor cell invadopodia:invasive protrusions that orchestrate metastasis[J].Trends Cell Biol,2017,27(8):595-607.
2 黄蕾,滕春莹,雷鹏,等.伪足,有氧糖酵解与肿瘤细胞迁移的研究进展[J].癌变·畸变·突变,2020,32(1):72-75.
3 Sandquist JC,Larson ME,Hine KJ.Myosin-10 independently influences mitotic spindle structure and mitotic progression[J].Cytoskeleton,2016,73(7):351-364.
4 Solc CK,Derfler BH,Duyk GM,et al.Molecular cloning of myosins from bullfrog saccular macula:a candidate for the hair cell adaptation motor[J].Auditory Neurosci,1994,1:61-75.
5 Courson DS,Cheney RE.Myosin-X and disease[J].Exp Cell Res,2015,334(1):10-15.
6 Pi X,Ren R,Kelley R,et al.Sequential roles for myosin-X in BMP6-dependent filopodial extension,migration,and activation of BMP receptors[J].J Cell Biol,2007,179(7):1569-1582.
7 Bachg AC,Horsthemke M,Skryabin BV,et al.Phenotypic analysis of Myo10 knockout(Myo10(tm2/tm2))mice lacking full-length(motorized)but not brain-specific headless myosin X[J].Sci Rep,2019,9(1):597.
8 Zhang H,Berg JS,Li Z,et al.Myosin-X provides a motor-based link between integrins and the cytoskeleton[J].Nat Cell Biol,2004,6(6):523-531.
9 Lai M,Guo Y,Ma J,et al.Myosin X regulates neuronal radial migration through interacting with N-cadherin[J].Front Cell Neurosci,2015,9:326.
10 Zhang J,Li Y,Qi J,et al.Circ-calm4 serves as an miR-337-3p sponge to regulate Myo10(Myosin 10)and promote pulmonary artery smooth muscle proliferation[J].Hypertension,2020,75(3):668-679.
11 Tasca A,Astleford K,Lederman A,et al.Regulation of osteoclast differentiation by myosin X[J].Sci Rep,2017,7(1):7603.
12 Mao Y,Yang D,He J,et al.Epidemiology of lung cancer[J].Surg Oncol Clin N Am,2016,25(3):439-445.
13 Sun Y,Ai X,Shen S,et al.NF-κB-mediated miR-124 suppresses metastasis of non-small-cell lung cancer by targeting MYO10[J].Oncotarget,2015,6(10):8244-8254.
14 Dvornikov D,Schneider MA,Ohse S,et al.Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response[J].Sci Rep,2018,8(1):9517.
15 Summerbell ER,Mouw JK.Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning[J].Sci Adv,2020,6(30):6197.
16 Schito L,Rey S.Hypoxic pathobiology of breast cancer metastasis[J].Biochim Biophys Acta Rev Cancer,2017,1868(1):239-245.
17 Cao R,Chen J,Zhang X,et al.Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis[J].Br J Cancer,2014,111(3):539-550.
18 Arjonen A,Kaukonen R,Mattila E,et al.Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis[J].J Clin Invest,2014,124(3):1069-1082.
19 Chen CP,Sun ZL,Lu X,et al.MiR-340 suppresses cell migration and invasion by targeting MYO10 in breast cancer[J].Oncol Rep,2016,35(2):709-716.
20 刘恒昌,魏然,李春香,等.NOX4在结肠癌组织中的表达及与预后的关系[J].实用肿瘤学杂志,2020,34(5):391-397.
21 Zhu XJ,Wang CZ,Dai PG,et al.Myosin X regulates netrin receptors and functions in axonal path-finding[J].Nat Cell Biol,2007,9(2):184-192.
22 Liu Y,Peng Y,Dai PG,et al.Differential regulation of myosin X movements by its cargos,DCC and neogenin[J].J Cell Sci,2012,125(3):751-762.
23 欧海斌,隋铭,邵晶,等.非传统型肌球蛋白Myo10对结肠癌细胞SW620生长的影响及其机制[J].武汉大学学报(医学版),2019,40(4):552-557.
24 Zhang X,Fang Q,Ma Y,et al.Protease activated receptor 2 mediates tryptase-induced cell migration through MYO10 in colorectal cancer[J].Am J Cancer Res,2019,9(9):1995-2006.
25 Mallepalli S,Gupta MK,Vadde R.Neuroblastoma:an updated review on biology and treatment[J].Curr Drug Metab,2019,20(13):1014-1022.
26 Wang X,Li J,Xu X,et al.miR-129 inhibits tumor growth and potentiates chemosensitivity of neuroblastoma by targeting MYO10[J].Biomed Pharmacother,2018,103:1312-1318.
27 Wang SY,Wang X,Zhang CY.LncRNA SNHG7 enhances chemoresistance in neuroblastoma through cisplatin-induced autophagy by regulating miR-329-3p/MYO10 axis[J].Eur Rev Med Pharmacol Sci,2020,24(7):3805-3817.
28 Lugović-Mihić L,Ćesić D,Vuković P,et al.Melanoma development:current knowledge on melanoma pathogenesis[J].Acta Dermatovenerol Croat,2019,27(3):163-168.
29 Tokuo H,Bhawan J,Coluccio LM.Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis[J].Sci Rep,2018,8(1):10449.
30 Makowska KA,Hughes RE,White KJ,et al.Specific myosins control actin organization,cell morphology,and migration in prostate cancer cells[J].Cell Rep,2015,13(10):2118-2125.
31 Bray F,Ferlay J,Soerjomataram I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.
32 He JH,Chen JG,Zhang B,et al.Elevated MYO10 predicts poor prognosis and its deletion hampers proliferation and migration potentials of cells through rewiring PI3K/Akt signaling in cervical cancer[J].Technol Cancer Res Treat,2020,19(19):153303382093677.
33 Umeki N,Jung HS,Sakai T,et al.Phospholipid-dependent regulation of the motor activity of myosin X[J].Nat Struct Mol Biol,2011,18(7):783-788.
34 Uhl J,Gujarathi S,Waheed AA,et al.Myosin-X is essential to the intercellular spread of HIV-1 Nef through tunneling nanotubes[J].J Cell Commun Signal,2019,13(2):209-224.

[1]	陈莉莉, 刘玉琴, 丁高恒, 苏海翔. 甘肃省恶性肿瘤流行情况及防控现状[J]. 实用肿瘤学杂志, 2021, 35(3): 254-257.
[2]	潘红艳, 李爱萍, 李强. 脂肪因子Omentin-1与肿瘤相关性的研究[J]. 实用肿瘤学杂志, 2021, 35(3): 282-286.
[3]	郑志远,综述,曲国蕃(审校). 长链非编码RNA SNHG3在恶性肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2021, 35(1): 50-54.
[4]	杨思琦,宋启斌,李清清(综述),姚颐(审校). 靶向抑制FGFRs信号在治疗恶性肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2021, 35(1): 73-77.
[5]	党瑶,皇甫辉,秦艺骁,车琴,郝晓龙(综述),王斌全(审校). 头颈部鳞状细胞癌转移机制及其影响因素研究进展[J]. 实用肿瘤学杂志, 2021, 35(1): 78-82.
[6]	鲍瑜,朱立建(综述),钱江(审校). 抗血管生成药物治疗肺癌脑转移的研究新进展[J]. 实用肿瘤学杂志, 2021, 35(1): 91-96.
[7]	文洪梅, 陈杨, 石青萍, 任思颖, 高娇, 秦明芳. 2016年云南省肿瘤登记地区恶性肿瘤的发病和死亡分析[J]. 实用肿瘤学杂志, 2020, 34(6): 485-490.
[8]	相智声, 马晶昱, 钟文玲, 陈铁晖, 林永添, 江惠娟, 周衍. 福建省2016年恶性肿瘤发病与死亡分析[J]. 实用肿瘤学杂志, 2020, 34(6): 491-494.
[9]	牛明, 于歌. 促进乳腺癌增殖转移和肿瘤干细胞特征的研究[J]. 实用肿瘤学杂志, 2020, 34(6): 518-523.
[10]	李云雪, 王刚, 孙备, 左倩, 武林枫. 甲状腺乳头状癌颈部淋巴结转移的处理态度和诊疗现状[J]. 实用肿瘤学杂志, 2020, 34(6): 530-534.
[11]	李建昕, 沈彬杰, 王璇. 恶性肿瘤社区随访模式的研究进展[J]. 实用肿瘤学杂志, 2020, 34(6): 540-543.
[12]	宋家羽, 冯越, 王棹, 张云艳. 外泌体与妇科恶性肿瘤相关性的最新研究进展[J]. 实用肿瘤学杂志, 2020, 34(6): 571-575.
[13]	袁瑶, 周显礼. 乳腺癌超声特征与腋窝淋巴结转移相关性的研究进展[J]. 实用肿瘤学杂志, 2020, 34(6): 576-580.
[14]	董满库, 姜福全, 林海冠, 孙晓敏, 刘景欣, 胡刚, 杨建武. lncRNA BLACAT1靶向LEMD1促进结直肠癌细胞的增殖和转移[J]. 实用肿瘤学杂志, 2020, 34(5): 418-424.
[15]	付强, 李威, 满文玲, 李伟, 杨坡. 微波消融治疗甲状腺乳头状癌术后淋巴结转移的临床研究和疗效观察[J]. 实用肿瘤学杂志, 2020, 34(5): 436-439.

MYO10与恶性肿瘤的研究进展

Research progress of MYO10 and malignant tumors

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价