UCA1在乳腺癌中的研究现状和应用展望

doi:10.11904/j.issn.1002-3070.2022.03.013

摘要/Abstract

摘要： 乳腺癌是全球女性最为常见的恶性肿瘤,其发生发展与遗传、环境、激素水平等多种因素相关。近年研究发现,长链非编码RNA(lncRNAs)在乳腺癌的发生发展中发挥了重要作用。尿路上皮癌相关1(UCA1)基因是lncRNA的一种,最早在膀胱癌组织中被发现而命名,在胃癌、结直肠癌、恶性黑色素瘤和卵巢癌等多种恶性肿瘤中也可见表达上调。本文对UCA1在乳腺癌中的相关作用及机制进行了综述,旨在了解UCA1在乳腺癌发生发展中的作用,以其为乳腺癌的预防、诊断和复发提供新指标以及治疗新靶点。

关键词: 尿路上皮癌相关1, 长链非编码RNA, 乳腺癌

Abstract: Breast cancer is the most common malignant tumor in women worldwide,and its occurrence and development are related to various factors such as heredity,environment,and hormone levels.Recent studies have found that long non-coding RNAs(lncRNAs)play an important role in the occurrence and development of breast cancer.The urothelial cancer-associated 1(UCA1)gene is a kind of lncRNA,which was first discovered and named in bladder cancer,and its expression was up-regulated in various malignant tumors such as gastric cancer,colorectal cancer,malignant melanoma,and ovarian cancer.This article reviews the relevant roles and mechanisms of UCA1 in breast cancer.It aims to understand the role of UCA1 in the occurrence and development of breast cancer,to provide new indicators and new therapeutic targets for the prevention,diagnosis and recurrence of breast cancer.

Key words: Urothelial cancer-associated 1, long non-coding RNAs, Breast cancer

中图分类号:

R392

杨姝娅, 刘文慧, 骆耐香. UCA1在乳腺癌中的研究现状和应用展望[J]. 实用肿瘤学杂志, 2022, 36(3): 263-267.

YANG Shuya, LIU Wenhui, LUO Naixiang. Research status and application prospect of UCA1 in breast cancer[J]. Journal of Practical Oncology, 2022, 36(3): 263-267.

0
/ / 推荐

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2022.03.013

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2022/V36/I3/263

参考文献

1 Sung H,Ferlay J,Siegel RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2021,71(3):209-249.
2 Sharma U,Barwal TS,Malhotra A,et al.Long non-coding RNA TINCR as potential biomarker and therapeutic target for cancer[J].Life Sci,2020,257:118035.
3 Ransohoff JD,Wei Y,Khavari PA.The functions and unique features of long intergenic non-coding RNA[J].Nat Rev Mol Cell Biol,2018,19(3):143-157.
4 Wang H,Guan Z,He K,et al.LncRNA UCA1 in anti-cancer drug resistance[J].Oncotarget,2017,8(38):64638-64650.
5 Xue M,Chen W,Li X.Urothelial cancer associated 1:a long non-coding RNA with a crucial role in cancer[J].J Cancer Res Clin Oncol,2016,142(7):1407-1419.
6 Sun L,Liu L,Yang J,et al.SATB1 3′-UTR and lncRNA-UCA1 competitively bind to miR-495-3p and together regulate the proliferation and invasion of gastric cancer[J].J Cell Biochem,2019,120(4):6671-6682.
7 Wei H,Qiu YQ,Zeng QS,et al.LncRNA UCA1 regulates proliferation,migration and invasion of cervical cancer cells by targeting miR-145[J].Eur Rev Med Pharmacol Sci,2020,24(7):3555-3564.
8 Luan Y,Li X,Luan Y,et al.Circulating lncRNA UCA1 promotes malignancy of colorectal cancer via the miR-143/MYO6 axis[J].Mol Ther Nucleic Acids,2020,19:790-803.
9 Song F,Li L,Liang D,et al.Knockdown of long non-coding RNA urothelial carcinoma associated 1 inhibits colorectal cancer cell proliferation and promotes apoptosis via modulating autophagy[J].J Cell Physiol,2019,234(5):7420-7434.
10 Li ZY,Wang XL,Dang Y,et al.Long non-coding RNA UCA1 promotes the progression of paclitaxel resistance in ovarian cancer by regulating the miR-654-5p/SIK2 axis[J].Eur Rev Med Pharmacol Sci,2020,24(2):591-603.
11 Pei S,Chen J,Lu J,et al.The long non-coding RNA UCA1 negatively regulates melanogenesis in melanocytes[J].J Invest Dermatol,2020,140(1):152-163.
12 Han C,Tang F,Chen J,et al.Knockdown of lncRNA-UCA1 inhibits the proliferation and migration of melanoma cells through modulating the miR-28-5p/HOXB3 axis[J].Exp Ther Med,2019,17(5):4294-4302.
13 李梦,王超群,周云,等.长链非编码RNA UCA1在乳腺癌中的作用及机制研究[J].徐州医科大学学报,2020,40(3):190-193.
14 Ghafouri-Fard S,Taheri M.UCA1 long non-coding RNA:an update on its roles in malignant behavior of cancers[J].Biomed Pharmacother,2019,120:109459.
15 Huang J,Zhou N,Watabe K,et al.Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27(Kip1)[J].Cell Death Dis,2014,5(1):e1008.
16 Razavipour SF,Harikumar KB,Slingerland JM.P27 as a transcriptional regulator:new roles in development and cancer[J].Cancer Res,2020,80(17):3451-3458.
17 Fan Y,Shen B,Tan M,et al.Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling[J].FEBS J,2014,281(7):1750-1758.
18 O′day E,Lal A.MicroRNAs and their target gene networks in breast cancer[J].Breast Cancer Res,2010,12(2):201.
19 Liao SC,Li JX,Yu L,et al.Protein tyrosine phosphatase 1B expression contributes to the development of breast cancer[J].J Zhejiang Univ Sci B,2017,18(4):334-342.
20 Li Y,Zeng Q,Qiu J,et al.Long non-coding RNA UCA1 promotes breast cancer by upregulating PTP1B expression via inhibiting miR-206[J].Cancer Cell Int,2019,19:275.
21 陈承,黄静,耿旭洋,等.shRNA干扰长链非编码RNA UCA1对乳腺癌移植瘤模型肿瘤生长的抑制作用[J].武汉大学学报(医学版),2019,40(4):534-539.
22 Xue M,Pang H,Li X,et al.Long non-coding RNA urothelial cancer-associated 1 promotes bladder cancer cell migration and invasion by way of the hsa-miR-145-ZEB1/2-FSCN1 pathway[J].Cancer Sci,2016,107(1):18-27.
23 Xiao C,Wu CH,Hu HZ.LncRNA UCA1 promotes epithelial-mesenchymal transition(EMT)of breast cancer cells via enhancing Wnt/beta-catenin signaling pathway[J].Eur Rev Med Pharmacol Sci,2016,20(13):2819-2824.
24 Kim MH,Kim J.Role of YAP/TAZ transcriptional regulators in resistance to anti-cancer therapies[J].Cell Mol Life Sci,2017,74(8):1457-1474.
25 Zhu HY,Bai WD,Ye XM,et al.Long non-coding RNA UCA1 desensitizes breast cancer cells to trastuzumab by impeding miR-18a repression of Yes-associated protein 1[J].Biochem Biophys Res Commun,2018,496(4):1308-1313.
26 Gu W,Katz Z,Wu B,et al.Regulation of local expression of cell adhesion and motility-related mRNAs in breast cancer cells by IMP1/ZBP1[J].J Cell Sci,2012,125(Pt 1):81-91.
27 Zhou Y,Meng X,Chen S,et al.IMP1 regulates UCA1-mediated cell invasion through facilitating UCA1 decay and decreasing the sponge effect of UCA1 for miR-122-5p[J].Breast Cancer Res,2018,20(1):32.
28 Choi J,Gyamfi J,Jang H,et al.The role of tumor-associated macrophage in breast cancer biology[J].Histol Histopathol,2018,33(2):133-145.
29 Chen S,Shao C,Xu M,et al.Macrophage infiltration promotes invasiveness of breast cancer cells via activating long non-coding RNA UCA1[J].Int J Clin Exp Pathol,2015,8(8):9052-9061.
30 Li Z,Niu H,Qin Q,et al.LncRNA UCA1 mediates resistance to cisplatin by regulating the miR-143/FOSL2-signaling pathway in ovarian cancer[J].Mol Ther Nucleic Acids,2019,17:92-101.
31 Chen X,Wang Z,Tong F,et al.LncRNA UCA1 promotes gefitinib resistance as a ceRNA to target FOSL2 by sponging miR-143 in non-small cell lung cancer[J].Mol Ther Nucleic Acids,2020,19:643-653.
32 Dai Q,Zhang T,Pan J,et al.LncRNA UCA1 promotes cisplatin resistance in gastric cancer via recruiting EZH2 and activating PI3K/AKT pathway[J].J Cancer,2020,11(13):3882-3892.
33 Li Z,Yu D,Li H,et al.Long non-coding RNA UCA1 confers tamoxifen resistance in breast cancer endocrinotherapy through regulation of the EZH2/p21 axis and the PI3K/AKT signaling pathway[J].Int J Oncol,2019,54(3):1033-1042.
34 Giordano A,Avantaggiati ML.P300 and CBP:partners for life and death[J].J Cell Physiol,1999,181(2):218-230.
35 Wu C,Luo J.Long non-coding RNA(lncRNA)urothelial carcinoma-associated 1(UCA1)enhances tamoxifen resistance in breast cancer cells via inhibiting mTOR signaling pathway[J].Med Sci Monit,2016,22:3860-3867.
36 Czerwinska P,Kaminska B.Regulation of breast cancer stem cell features[J].Contemp Oncol(Pozn),2015,19(1A):A7-A15.
37 Liu H,Wang G,Yang L,et al.Knockdown of long non-coding RNA UCA1 increases the tamoxifen sensitivity of breast cancer cells through inhibition of Wnt/beta-catenin pathway[J].PLoS One,2016,11(12):e0168406.
38 Wu F,Huang W,Wang X.MicroRNA-18a regulates gastric carcinoma cell apoptosis and invasion by suppressing hypoxia-inducible factor-1α expression[J].Exp Ther Med,2015,10(2):717-722.
39 Li X,Wu Y,Liu A,et al.Long non-coding RNA UCA1 enhances tamoxifen resistance in breast cancer cells through a miR-18a-HIF1alpha feedback regulatory loop[J].Tumour Biol,2016,37(11):14733-14743.
40 Liu C,Jiang F,Zhang X,et al.Long non-coding RNA UCA1 modulates paclitaxel resistance in breast cancer via miR-613/CDK12 axis[J].Cancer Manag Res,2020,12:2777-2788.
41 Wei Y,Lai X,Yu S,et al.Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells[J].Breast Cancer Res Treat,2014,147(2):423-431.
42 Xu CG,Yang MF,Ren YQ,et al.Exosomes mediated transfer of lncRNA UCA1 results in increased tamoxifen resistance in breast cancer cells[J].Eur Rev Med Pharmacol Sci,2016,20(20):4362-4368.

[1]	杨子涵, 许守平, 庞达. 乳腺癌发生腋窝外三角组织转移特点与影响因素分析[J]. 实用肿瘤学杂志, 2022, 36(3): 226-232.
[2]	何伟丹, 李志高. FSIP1促进乳腺癌细胞迁移和侵袭并导致患者不良预后[J]. 实用肿瘤学杂志, 2022, 36(3): 233-238.
[3]	刘欣欣, 姚欣卉, 孙跃峰, 缪美琪, 陈晶. 乳腺癌微环境中趋化因子CCL20作用的研究进展[J]. 实用肿瘤学杂志, 2022, 36(3): 250-254.
[4]	刘婉莹, 庞达. 乳腺浸润性微乳头状癌转移机制的研究进展[J]. 实用肿瘤学杂志, 2022, 36(3): 268-272.
[5]	陈函, 罗晓勇, 李朝萍, 郭彩茹, 鞠文翠, 翟秧秧, 师鑫鹏. lncRNA CASC2对结直肠癌细胞功能及血管生成的影响[J]. 实用肿瘤学杂志, 2022, 36(2): 111-118.
[6]	王洪英, 李岩, 韩鑫浩, 魏孝礼, 贾慧珣, 袁文娟, 张秋菊. 基于免疫相关lncRNAs的胃癌早期诊断和预后风险模型的构建和验证[J]. 实用肿瘤学杂志, 2022, 36(2): 119-126.
[7]	孙元元, 张苧之, 曹孟儒. 乳腺癌肺转移机制及治疗进展[J]. 实用肿瘤学杂志, 2022, 36(2): 173-177.
[8]	侯建勋, 王洪斌. 外泌体对乳腺癌诊疗一体化影响的研究进展[J]. 实用肿瘤学杂志, 2022, 36(2): 178-182.
[9]	陈赫, 王秋程, 程文. 自动乳腺超声诊断系统在乳腺癌方面的应用进展[J]. 实用肿瘤学杂志, 2022, 36(2): 193-196.
[10]	李伟华, 张广凤, 马骊骊, 何品, 王雯, 李顶夫. 基于TCGA数据库代谢相关基因构建乳腺癌预后模型[J]. 实用肿瘤学杂志, 2022, 36(1): 37-43.
[11]	曹世玉, 姜永冬. 基因表达与多基因检测以及生物标志物对Luminal A型乳腺癌预后的影响[J]. 实用肿瘤学杂志, 2022, 36(1): 89-93.
[12]	罗波, 张曲, 郑红梅, 梁新军, 周小妹, 吴新红. SRT联合拉帕替尼治疗HER2阳性乳腺癌脑转移疗效及预后分析[J]. 实用肿瘤学杂志, 2021, 35(6): 523-528.
[13]	史润泽, 李志高. 三阴性乳腺癌各亚型精准医疗策略研究进展[J]. 实用肿瘤学杂志, 2021, 35(6): 529-533.
[14]	纪雷, 纪道林, 鲍冬冬, 谭刚. lncRNA在肝细胞癌索拉非尼耐药中的最新研究进展[J]. 实用肿瘤学杂志, 2021, 35(6): 562-567.
[15]	李响, 胡洋, 张清媛. 肿瘤突变负荷作为乳腺癌免疫治疗的新兴生物标志物的研究进展[J]. 实用肿瘤学杂志, 2021, 35(6): 568-571.