1 Guo H,Wang Y,Cui H,et al.Copper induces spleen damage through modulation of oxidative stress,apoptosis,DNA damage,and inflammation[J].Biol Trace Elem Res,2022,200(2):669-677. 2 Zischka H,Einer C.Mitochondrial copper homeostasis and its derailment in Wilson disease[J].Int J Biochem Cell Biol,2018,102:71-75. 3 Tsvetkov P,Coy S,Petrova B,et al.Copper induces cell death by targeting lipoylated TCA cycle proteins[J].Science,2022,375(6586):1254-1261. 4 Sung H,Ferlay J,Siegel RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2021,71(3):209-249. 5 Cao B,Lei YT,Xue H,et al.Changes in the serum concentrations of essential trace metals in patients with benign and malignant breast cancers[J].Biol Trace Elem Res,2022,200(8):3537-3544. 6 Festa RA,Thiele DJ.Copper:an essential metal in biology[J].Curr Biol,2011,21(21):R877-883. 7 Lin C,Zhang Z,Wang T,et al.Copper uptake by DMT1:a compensatory mechanism for CTR1 deficiency in human umbilical vein endothelial cells[J].Metallomics,2015,7(8):1285-1289. 8 Chen J,Jiang Y,Shi H,et al.The molecular mechanisms of copper metabolism and its roles in human diseases[J].Pflugers Arch,2020,472(10):1415-1429. 9 Lee JY,Kim YH,Kim TW,et al.New novel mutation of the ATP7B gene in a family with Wilson disease[J].J Neurol Sci,2012,313(1-2):129-131. 10 Jiang X,Stockwell BR,Conrad M.Ferroptosis:mechanisms,biology and role in disease[J].Nat Rev Mol Cell Biol,2021,22(4):266-282. 11 Zheng P,Zhou C,Lu L,et al.Elesclomol:a copper ionophore targeting mitochondrial metabolism for cancer therapy[J].J Exp Clin Cancer Res,2022,41(1):271. 12 Nagai M,Vo NH,Shin Ogawa L,et al.The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells[J].Free Radic Biol Med,2012,52(10):2142-2150. 13 Yang L,Zhang Y,Wang Y,et al.Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity:a pan-cancer analysis[J].Front Pharmacol,2022,13:938134. 14 Tsvetkov P,Detappe A,Cai K,et al.Mitochondrial metabolism promotes adaptation to proteotoxic stress published correction appears in Nat Chem Biol[J].Nat Chem Biol,2019,15(7):681-689. 15 Rowland EA,Snowden CK,Cristea IM.Protein lipoylation:an evolutionarily conserved metabolic regulator of health and disease[J].Curr Opin Chem Biol,2018,42:76-85. 16 Li X,Dai Z,Liu J,et al.Characterization of the functional effects of ferredoxin 1 as a cuproptosis biomarker in cancer[J].Front Genet,2022,13:969856. 17 Sha S,Si L,Wu X,et al.Prognostic analysis of cuproptosis-related gene in triple-negative breast cancer[J].Front Immunol,2022,13:922780. 18 Xu B,Hu X,Feng J,et al.Chinese expert consensus on the clinical diagnosis and treatment of advanced breast cancer(2018)[J].Cancer,2020,126(S16):3867-3882. 19 Kamiya T.Copper in the tumor micro environment and tumor metastasis[J].J Clin Biochem Nutr,2022,71(1):22-28. 20 Baharvand M,Manifar S,Akkafan R,et al.Serum levels of ferritin,copper,and zinc in patients with oral cancer[J].Biomed J,2014,37(5):331-356. 21 Booth BA,Sartorelli AC.Synergistic interaction of kethoxal bis(thiosemicarbazone)and cupric ions in sarcoma 180[J].Nature,1966,210(5031):104-105. 22 Li Y.Copper homeostasis:Emerging target for cancer treatment[J].IUBMB Life,2020,72(9):1900-1908. 23 Goodman VL,Brewer GJ,Merajver SD.Control of copper status for cancer therapy[J].Current cancer drug targets,2005(7):543-549. 24 Liang ZD,Long Y,Tsai WB,et al.Mechanistic basis for overcoming platinum resistance using copper chelating agents[J].Mol Cancer Ther,2012,11(11):2483-2494. 25 Yip NC,Fombon IS,Liu P,et al.Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties[J].Br J Cancer,2011,104(10):1564-1574. 26 Allensworth JL,Evans MK,Bertucci F,et al.Disulfiram(DSF)acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer[J].Mol Oncol,2015,9(6):1155-1168. 27 McMahon A,Chen W,Li F.Old wine in new bottles:Advanced drug delivery systems for disulfiram-based cancer therapy[J].J Control Release,2020,319:352-359. 28 Han D,Wu G,Chang C,et al.Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway[J].Oncotarget,2015,6(38):40907-40919. 29 Feng Y,Zeng JW,Ma Q,et al.Serum copper and zinc levels in breast cancer:A meta-analysis[J].J Trace Elem Med Biol,2020,62:126629. 30 MacDonald G,Nalvarte I,Smirnova T,et al.Memo is a copper-dependent redox protein with an essential role in migration and metastasis[J].Sci Signal,2014,7(329):ra56. 31 Li L,Li L,Sun Q.High expression of cuproptosis-related SLC31A1 gene in relation to unfavorable outcome and deregulated immune cell infiltration in breast cancer:an analysis based on public databases[J].BMC Bioinformatics,2022,23(1):1-15. 32 Blockhuys S,Wittung-Stafshede P.Copper chaperone Atox1 plays role in breast cancer cell migration[J].Biochem Biophys Res Commun,2017,483(1):301-304. 33 Ahn SG,Dong SM,Oshima A,et al.LOXL2 expression is associated with invasiveness and negatively influences survival in breast cancer patients[J].Breast Cancer Res Treat.2013;141(1):89-99. 34 Karginova O,Weekley CM,Raoul A,et al.Inhibition of copper transport induces apoptosis in triple-negative breast cancer cells and suppresses tumor angiogenesis[J].Mol Cancer Ther,2019,18(5):873-885. 35 Liu L,Yi J,Yuan J,et al.FOXO1 overexpression is correlated with poor prognosis in epithelial ovarian cancer[J].Cancer Biomark,2020,28(1):1-8. 36 Zeng R,Peng B,Peng E.Downregulated copper homeostasis-related gene FOXO1 as a novel indicator for the prognosis and immune response of breast cancer.[J].J Immunol Res,2022,2022:9140461. 37 Feng Q,Zhang Y,Zhang W,et al.Tumor-targeted and multi-stimuli responsive drug delivery system for near-infrared light induced chemo-phototherapy and photoacoustic tomography[J].Acta Biomaterialia,2016,38:129-142. 38 Shrestha S,Wu J,Sah B,et al.X-ray induced photodynamic therapy with copper-cysteamine nanoparticles in mice tumors[J].Proc Natl Acad Sci U S A.2019;116(34):16823-16828. 39 Zheng R,Cheng Y,et al.Biodegradable copper-based nanoparticles augmented chemodynamic therapy through deep penetration and suppressing antioxidant activity in tumors[J].Adv Healthc Mater,2021,10(14):e2100412. 40 Voli F,Valli E,Lerra L,et al.Intratumoral copper modulates PD-L1 expression and influences tumor immune evasion[J].Cancer Res,2020,80(19):41. |