实用肿瘤学杂志 ›› 2017, Vol. 31 ›› Issue (1): 73-77.doi: 10.11904/j.issn.1002-3070.2017.01.016

• 综述 • 上一篇    下一篇

经典型霍奇金淋巴瘤表观遗传学异常及其对免疫逃逸的影响

刘晓健1, 龙志国2 综述, 乔忠杰3 审校   

  1. 1.复旦大学上海肿瘤中心肿瘤内科,复旦大学上海医学院肿瘤学系(上海 200032);
    2.复旦大学附属浦东医院;
    3.哈尔滨医科大学附属肿瘤医院泌尿外科
  • 收稿日期:2016-10-08 出版日期:2017-02-28 发布日期:2017-02-20
  • 通讯作者: 刘晓健,E-mail:lxj068@hotmail.com
  • 作者简介:刘晓健,男,(1968-),博士,副主任医师,从事肿瘤的表观遗传学方向的研究

Research progress in epigenetic aberrant in classic Hodgkin lymphoma

LIU Xiaojian1, LONG Zhiguo2, QIAO Zhongjie3   

  1. 1.Department of Medical Oncology,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical Collage,Fudan University,Shanghai 200032,China;
    2.Department of Medical Oncology,Fudan University Pudong Hospital,Fudan University;
    3.Department of Urology,The Affiliated Cancer Hospital of Harbin Medical University
  • Received:2016-10-08 Online:2017-02-28 Published:2017-02-20

摘要:

经典型霍奇金淋巴瘤(Classic Hodgkin lymphoma,cHL)恶性表型的维持和表观遗传学有一定关系,表观遗传学改变主要包括组蛋白乙酰化异常和DNA甲基化异常,组蛋白去乙酰化酶抑制剂(Histone deacetylases inhibitors,HDACis)的临床研究取得了进展。表观遗传学异常和cHL的免疫逃逸密切相关,甲基转移酶抑制剂、HDACis和免疫检测点阻断剂具有协同作用,采用联合治疗策略对进一步提高cHL的治愈率有重大意义。

关键词: 经典型霍奇金淋巴瘤, 甲基化, 乙酰化, 免疫逃逸, 免疫检测点抑制剂

Abstract:

The malignant phenotype of classical Hodgkin lymphoma(cHL)is partly maintained by epigenetic aberrant,of which consisted mainly abnormal histone methylation and deacetylation.Progress has been made in clinical trials related to the histone deacetylases inhibitors(HDACis)in cHL.There is a close association noted between the epigenetic aberrants and the immune escape in cHL.DNA methyltransferase(DNMT)inhibitors,HDACis and immune checkpoint blockade have shown synergistic effects.Further study to improve the cure rate in cHL by combination strategy is of significant importance.

Key words: Classical Hodgkin lymphoma, Methylation, Acetylation, Immune escape, Immune checkpoint inhibitor

中图分类号: