微创外科治疗联合药物对局限性鼻咽癌微小浸润灶的近远期疗效分析

doi:10.11904/j.issn.1002-3070.2017.03.008

摘要/Abstract

摘要： 目的观察对局限性鼻咽癌微小浸润灶进行微创外科治疗联合化疗药物治疗的近期和远期疗效变化,以明确鼻咽癌患者联合治疗的必要性。方法选取我院2011年3月—2011年9月就诊的微小浸润灶的局限性鼻咽癌患者62例,通过随机数字表法将患者分为观察组(应用微创外科的经鼻内镜鼻咽切除病灶联合术后化疗药物采用顺铂、5-氟尿嘧啶结合化疗)和对照组(单一应用微创外科治疗经鼻内镜鼻咽切除病灶),观察两组患者的术后1年、5年的有效率、生存率、患者术后的生活质量情况,并加以分析。结果观察组患者术后1年有效率达83.87%、生存率为100.00%;对照组1年有效率为58.06%、生存率为87.10%;有效率观察组比较对照组有明显差异(P＜0.05);术后5年患者的生存率、有效率,观察组均明显高于对照组(P＜0.05);观察组患者术后1年、术后5年评分均显著高于对照组(P＜0.05)。结论应用微创外科的经鼻内镜鼻咽切除病灶联合术后化疗药物采用顺铂、5-氟尿嘧啶结合进行药物治疗能够显著提高患者近期和远期术后生存率、远期有效率以及患者的肿瘤术后的生存质量,适合临床推广应用。

关键词: 局限性鼻咽癌, 微小浸润灶, 微创外科治疗, 药物, 疗效

Abstract: Objective The objective of this study was to observe the short-term and long-term curative effects of minimally invasive surgical treatment combined with chemotherapy of localized nasopharyngeal carcinoma in patients,and to clarify the necessity of combination therapy in patients with nasopharyngeal carcinoma.Methods Sixty-two patients with nasopharyngeal carcinoma were enrolled in our hospital from March 2011 to September 2011.The patients were divided into the observation and control groups by random number table method.The patients in observation group were given the application of minimally invasive surgery with postoperative combined chemotherapy with cisplatin and 5-fluorouracil after nasal endoscopic resection.The patients in the control group were given single application of minimally invasive surgical treatment of nasal endoscopic resection.The patients in two groups were observed the efficiency,survival rate and postoperative quality of life after surgery for 1 year or 5 years.Results The effective rate was 83.87% and 100% for the survival rate in the observation group after surgery for 1 year;the effective rate was 58.06% and 87.10% for the survival rate in the control group.There was significant different between the observation and control groups(P＜0.05).The survival and survival rates were significantly higher than those in the control group after surgery for 5 years(P＜0.05).After surgery 1 year,the scores of the patients in the observation group were significantly higher than those in the control group(P＜0.05).Conclusion The combination of cisplatin and 5-fluorouracil in the treatment of minimally invasive endoscopic nasopharyngeal resection combined with postoperative chemotherapy can significantly improve the short-and long-term survival rates,long-term effective rate,and quality of life in tumor patients after surgery.This is suitable for clinical application.

Key words: Localized nasopharyngeal carcinoma, Minimally invasive surgery, Minimally invasive surgery, Drug, Curative effect

中图分类号:

R739.6

李丹，王勇. 微创外科治疗联合药物对局限性鼻咽癌微小浸润灶的近远期疗效分析[J]. 实用肿瘤学杂志, 2017, 31(3): 234-237.

LI Dan,WANG Yong. Short-and long-term effects of minimally invasive surgical treatment combined with drugs on localized small foci of nasopharyngeal carcinoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(3): 234-237.

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