CTGF/CCN2在恶性肿瘤的发生发展及靶向治疗中的研究进展

doi:10.11904/j.issn.1002-3070.2017.04.014

摘要/Abstract

摘要： 目前恶性肿瘤的发病率日益上升,虽然我们一直探索肿瘤发生发展的机制及其治疗的途径,但是收获甚微。恶性肿瘤的发生发展机制十分复杂,与多种蛋白和基因相关联。结缔组织生长因子(Connective tissue growth factor,CTGF/CCN2)是一种分泌蛋白,属于CCN家族的成员,它在肿瘤的发生发展中起着非常重要的作用。本文概述了CTGF/CCN2蛋白的结构功能、在恶性肿瘤发生发展中的作用机制及靶向治疗中的最新研究进展。

关键词: CTGF/CCN2蛋白, 结构功能, 恶性肿瘤, 靶向治疗

Abstract: The current incidence of malignant tumors is increasing.Although we have been exploring the mechanism of tumor development and its treatment,its efficacy is little.Malignant tumor development mechanism is very complex,and a variety of proteins and genes involved.Connective tissue growth factor(CTGF,also known as CCN2)is a secreted protein,a member of the CCN family,which plays a very important role in the development and progression of tumors.This article summarizes the structure and function of CTGF /CCN2 protein,the mechanism of action in the development of malignant tumors and the latest research progress in targeted therapy.

Key words: CTGF/CCN2 protein, Structural function, Malignancy, Targeted therapy

中图分类号:

孙禹琪,陈秀玮. CTGF/CCN2在恶性肿瘤的发生发展及靶向治疗中的研究进展[J]. 实用肿瘤学杂志, 2017, 31(4): 363-366.

SUN Yuqi,CHEN Xiuwei. Research progress of CTGF/CCN2 in the development and targeted therapy of malignant tumor[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(4): 363-366.

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