外泌体lncRNA在鳞癌中的研究进展

doi:10.11904/j.issn.1002-3070.2023.02.012

摘要/Abstract

摘要： 外泌体是由各种细胞分泌的直径为30~150 nm小囊泡,通过运输关键的蛋白质和遗传物质(如miRNA,mRNA和DNA)在细胞通讯和表观遗传调控中发挥重要作用。长链非编码RNA(long non-coding RNA,lncRNA)是一种长度超过200个核苷酸的不编码蛋白质的RNA转录物,目前研究发现lncRNA是外泌体中包含的重要核酸分子,通过外泌体介导在肿瘤发生发展和调节肿瘤生物学功能中发挥重要作用。本文将对近年来外泌体lncRNA在鳞癌(Squamous cell carcinoma,SCC)的发生发展、早期诊断、治疗与预后等方面的作用及其应用前景进行综述,以期为后续研究提供参考。

关键词: 外泌体, 长链非编码RNA, 鳞状细胞癌

Abstract: Exosomes are small vesicles with a diameter of 30~150 nm secreted by various cells.They play an important role in cell communication and epigenetic regulation by transporting critical proteins and genetic materials such as miRNA,mRNA,and DNA.Long non-coding RNA(lncRNA)is an RNA transcript that is more than 200 nucleotides in length and does not encode a protein.Current studies have found that lncRNA is an important nucleic acid molecule contained in exosomes.It plays an important role in the occurrence and development of tumors,and the regulation of tumor biological function through exosome mediation.This paper reviews the development,early diagnosis,treatment and prognosis of exosome lncRNAs in squamous cell carcinoma(SCC)in recent years,as well as its application prospects,in order to provide reference for follow-up studies.

Key words: Exosomes, long non-coding RNA, Squamous cell carcinoma

中图分类号:

R782

周兴安, 苏尼特, 武旭, 达林泰, 德乐黑巴特尔. 外泌体lncRNA在鳞癌中的研究进展[J]. 实用肿瘤学杂志, 2023, 37(2): 160-163.

ZHOU Xingan, SU Nite, WU Xu, DA Lintai, DELEHEI Bateer. Research progress of exosomal lncRNA in squamous cell carcinoma[J]. Journal of Practical Oncology, 2023, 37(2): 160-163.

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链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2023.02.012

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2023/V37/I2/160

参考文献

1 Thomson PJ.Perspectives on oral squamous cell carcinoma prevention-proliferation,position,progression and prediction[J].J Oral Pathol Med,2018,47(9):803-807.
2 Bugshan A,Farooq I.Oral squamous cell carcinoma:metastasis,potentially associated malignant disorders,etiology and recent advancements in diagnosis[J].F1000Res,2020,9:229.
3 Zhu Q,Huang L,Yang Q,et al.Metabolomic analysis of exosomal-markers in esophageal squamous cell carcinoma[J].Nanoscale,2021,13(39):16457-16464.
4 Huang L,Wang Y,Chen J,et al.Long noncoding RNA PCAT1,a novel serum-based biomarker,enhances cell growth by sponging miR-326 in oesophageal squamous cell carcinoma[J].Cell Death Dis,2019,10(7):513.
5 Zhao W,Xie Q.Exosomal lncRNA-mediated intercellular communication promotes glioblastoma chemoresistance[J].Cancer Immunol Res,2021,9(12):1372.
6 Sun Z,Yang S,Zhou Q,et al.Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment[J].Mol Cancer,2018,17(1):82.
7 Li Z,Qin X,Bian W,et al.Exosomal lncRNA ZFAS1 regulates esophageal squamous cell carcinoma cell proliferation,invasion,migration and apoptosis via microRNA-124/STAT3 axis[J].J Exp Cancer Res,2019,38(1):477.
8 Xu M,Liu T,Dong F,et al.Exosomal lncRNA LINC01711 facilitates metastasis of esophageal squamous cell carcinoma via the miR-326/FSCN1 axis[J].Aging,2021,13(15):19776-19788.
9 Xu Y,Jiang E,Shao Z,et al.Long noncoding RNAs in the metastasis of oral squamous cell carcinoma[J].Front Oncol,2021,10:616717.
10 Song JW,Yi JL,Biao G,et al.Long non-coding RNA00152 slicing represses the growth and aggressiveness of hemangioma cell by modulating miR-139-5p[J].Biomed Pharmacother,2019,120:109385.
11 Li X,Rui B,Cao Y,et al.Long non-coding RNA LINC00152 acts as a sponge of miRNA-193b-3p to promote tongue squamous cell carcinoma progression[J].Oncol Lett,2020,19(3):2035-2042.
12 Jiang S,Wang H,Yang J.Low expression of long non-coding RNA LET inhibits carcinogenesis of cervical cancer[J].Int J Clin Exp Pathol,2015,8(1):806-811.
13 智亮辉,刘伟,李伟,等.lncRNA-ATB介导的上皮间质转化在胃癌进展中的机制研究[J].实用肿瘤学杂志,2022,36(3):208-213.
14 彭孟凡,李鸣,苗晋鑫,等.LncRNA在食管癌中的双重调控机制及其临床价值[J].中国比较医学杂志,2022,32(11):121-127.
15 Robertson N,Shchepachev V,Wright D,et al.A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis[J].Nature Communications,2022,13(1):649.
16 Yan S,Du L,Jiang X,et al.Evaluation of serum exosomal lncRNAs as diagnostic and prognostic biomarkers for esophageal squamous cell carcinoma[J].Cancer Manag Res,2020,12:9753-9763.
17 Teng Y,Kang H,Chu Y.Identification of an exosomal long noncoding RNA SOX2-OT in plasma as a promising biomarker for lung squamous cell carcinoma[J].Genet Test Mol Biomarkers,2019,23(4):235-240.
18 Chen Z,Chen Z,Xu S,et al.Corrigendum:lncRNA SOX2-OT/miR-30d-5p/PDK1 regulates PD-L1 checkpoint through the mTOR signaling pathway to promote non-small cell lung cancer progression and immune escape[J].Front Genet,2022,12:674856.
19 Shen Z,Li Q,Deng H,et al.Long non-coding RNA profiling in laryngeal squamous cell carcinoma and its clinical significance:potential biomarkers for LSCC[J].PloS One,2014,9(9):e108237.
20 Jin J,Huang Z,Lu X,et al.Bioinformatics analysis of aberrantly expressed exosomal lncRNAs in oral squamous cell carcinoma(CAL-27 vs.oral epithelial)cells[J].Oncol Lett,2020,20(3):2378-2386.
21 Kondo Y,Shinjo K,Katsushima K.Long non-coding RNAs as an epigenetic regulator in human cancers[J].Cancer Sci,2017,108(10):1927-1933.
22 Tan DSW,Chong FT,Leong HS,et al.Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma[J].Nat Med,2017,23(10):1167-1175.
23 万雪,叶婷,李婧媛,等.外泌体miRNAs及lncRNAs在乳腺癌中的作用研究进展[J].解放军医学杂志,2021,46(12):1245-1250.
24 Jiao Z,Yu A,Rong W,et al.Five-lncRNA signature in plasma exosomes serves as diagnostic biomarker for esophageal squamous cell carcinoma[J].Aging,2020,12(14):15002-15010.
25 Ding X,Zhang S,Deng X,et al.Serum exosomal lncRNA DLX6-AS1 is a promising biomarker for prognosis prediction of cervical cancer[J].Technol Cancer Res Treat,2021,20:1533033821990060.
26 Wang X,Yu H,Yu Z,et al.Exosomal lncRNA HEIH promotes cisplatin resistance in tongue squamous cell carcinoma via targeting miR-3619-5p/HDGF axis[J].Acta Histochen,2020,122(8):151647.
27 Gao Q,Fang X,Chen Y,et al.Exosomal lncRNA UCA1 from cancer-associated fibroblasts enhances chemoresistance in vulvar squamous cell carcinoma cells[J].J Obstet Gynaecol Res,2020,47(1):73-87.
28 Kang M,Ren M,Li Y,et al.Exosome-mediated transfer of lncRNA PART1 induces gefitinib resistance in esophageal squamous cell carcinoma via functioning as a competing endogenous RNA[J].J Exp Clin Cancer Res,2018,37(1):171.
29 Chi Y,Wang D,Wang J,et al.Long non-coding RNA in the pathogenesis of cancers[J].Cells,2019,8(9):1015.
30 Sahu A,Kose K,Kraehenbuehl L,et al.In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response.Nat Commun.2022,13(1):5312.
31 Zhang H,Wang Y,Liu Y,et al.Progress of long noncoding RNAs in anti-tumor resistance[J].Pathol Res Pract,2020,216(11):153215.
32 Sun Y,Wang J,Ma Y,et al.Radiation induces NORAD expression to promote ESCC radiotherapy resistance via EEPD1/ATR/Chk1 signalling and by inhibiting pri-miR-199a1 processing and the exosomal transfer of miR-199a-5p[J].J Exp Clin Cancer Res,2021,40(1):306.
33 Park EG,Pyo SJ,Cui Y,et al.Tumor immune microenvironment lncRNAs.[J]Brief Bioinform,2022,23(1):bbab504.

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